HDAC-IN-4

Product Name: HDAC-IN-4
CAS No.: 934828-12-3
Chemical Name: HDAC-IN-4
Synonyms: AZD9468;AZD-8025;HDAC-IN-4;Zabadinostat;CXD101 ，E0812;CXD101(AZD-9468);HDAC-IN-4 (CXD101;CXD101, 10 mM in DMSO;CXD 101;AZD9468;CXD-101;AZD 9468;CXD 101;AZD9468;CXD-101;AZD 9468;HDAC-IN-4
CBNumber: CB43152081
Molecular Formula: C24H29N5O
Formula Weight: 403.52
MOL File: 934828-12-3.mol

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HDAC-IN-4 Property

Boiling point:: 531.4±50.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:31.0(Max Conc. mg/mL);76.82(Max Conc. mM)
form: A crystalline solid
pka: 13.27±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21159
Product name: CXD101
Purity: ≥98%
Packaging: 500μg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 21159
Product name: CXD101
Purity: ≥98%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 21159
Product name: CXD101
Purity: ≥98%
Packaging: 5mg
Price: $505
Updated: 2024/03/01

Cayman Chemical

Product number: 21159
Product name: CXD101
Purity: ≥98%
Packaging: 10mg
Price: $884
Updated: 2024/03/01

ChemScene

Product number: CS-5964
Product name: CXD101
Purity: 99.14%
Packaging: 100mg
Price: $1070
Updated: 2021/12/16

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HDAC-IN-4 Chemical Properties,Usage,Production

Uses

Zabadinostat (CXD101) is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. Zabadinostat has no activity against HDAC class II. Zabadinostat has antitumor activity[1][2].

in vivo

Zabadinostat substantially reduces tumor size in murine xenograft lung (A549a) and colon (HT29) models at a dose of 50 mg/kg. Tumor reductions are found to be associated with increased histone acetylation and decreased HDAC enzyme activity^[2].
For Zabadinostat, after oral dosing in murine and canine models, peak plasma concentrations (C_max) are reached 1 to 2 hours after the dose and terminal half‐lives are 6 hours and 8 hours, respectively. After murine oral [¹⁴C]-Zabadinostat at a dose of 1.6 mg/kg (4 μmol/kg), tissue radioactivity peaked 3 to 6 hours after the dose and declined slowly thereafter with Zabadinostat‐related material still present in tissue 21 days after the dose^[2].

IC 50

HDAC1: 63 nM (IC₅₀); HDAC3: 550 nM (IC₅₀); HDAC2: 570 nM (IC₅₀)

References

[1] Eyre TA, et al. Predictive biomarkers for disease sensitivity in lymphoma - the holy grail for HDAC inhibitors? Oncotarget. 2018 Dec 18;9(99):37280-37281. DOI:10.18632/oncotarget.26460
[2] Eyre TA, et al. A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer. Cancer. 2019 Jan 1;125(1):99-108. DOI:10.1002/cncr.31791

HDAC-IN-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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HDAC-IN-4 Suppliers

China 50 United States 6 Global 56

EnliPharma Technology Co., Ltd

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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Beijing Jin Ming Biotechnology Co., Ltd.

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Musechem

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Twochem Co.Ltd.

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Angel Pharmatech, Ltd.

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934828-12-3, HDAC-IN-4Related Search:

HDAC-IN-4

AZD9468

CXD 101;AZD9468;CXD-101;AZD 9468;HDAC-IN-4

CXD101(AZD-9468)

CXD 101;AZD9468;CXD-101;AZD 9468

Benzamide, N-(2-aminophenyl)-4-[1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-4-piperidinyl]-

HDAC-IN-4 (CXD101

Zabadinostat

antitumor,HDAC2,orally,Histone deacetylases,histone,CXD101,CXD 101,inhibit,HDAC1,HDAC3,HDAC,acetylation,Inhibitor

N-(2-Aminophenyl)-4-(1-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)piperidin-4-yl)benzamide

CXD101, 10 mM in DMSO

AZD-8025

CXD101 ，E0812

934828-12-3