(±)13(14)-EpDPA
- Product Name
- (±)13(14)-EpDPA
- CAS No.
- 895127-64-7
- Chemical Name
- (±)13(14)-EpDPA
- Synonyms
- (±)13(14)-EpDPA;13(14)-Epoxy-Docosapentaenoic acid;4,7,10-Dodecatrienoic acid, 12-[3-(2Z,5Z)-2,5-octadien-1-yl-2-oxiranyl]-, (4Z,7Z,10Z)-;(4(Z),7(Z),10Z)-12-[3-(2(Z),5Z)-2,5-octadien-1-yl-2-oxiranyl]-4,7,10-dodecatrienoic acid
- CBNumber
- CB43152405
- Molecular Formula
- C22H32O3
- Formula Weight
- 344.49
- MOL File
- 895127-64-7.mol
(±)13(14)-EpDPA Property
- Boiling point:
- 462.8±33.0 °C(Predicted)
- Density
- 0.994±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/mL; DMSO: 20 mg/mL; Ethanol: 50 mg/mL; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
- pka
- 4.58±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- 10464
- Product name
- (±)13(14)-EpDPA
- Purity
- ≥95%
- Packaging
- 25μg
- Price
- $41
- Updated
- 2024/03/01
- Product number
- 10464
- Product name
- (±)13(14)-EpDPA
- Purity
- ≥95%
- Packaging
- 50μg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 10464
- Product name
- (±)13(14)-EpDPA
- Purity
- ≥95%
- Packaging
- 100μg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- 10464
- Product name
- (±)13(14)-EpDPA
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $642
- Updated
- 2024/03/01
(±)13(14)-EpDPA Chemical Properties,Usage,Production
Description
Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid (DHA; ) epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 μM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models.1 (±)13(14)-EpDPA and other epoxy metabolites of DHA are also reported to potently inhibit angiogenesis and tumor growth in in vitro assays.2
References
1. Morisseau, C., Inceoglu, B., Schmelzer, K., et al. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids J. Lipid Res. 51,3481-3490(2010).
2. Zhang, G., Panigrahy, D., Mahakian, L.M., et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis Proc. Natl. Acad. Sci. USA 110(16),6530-6535(2013).
(±)13(14)-EpDPA Preparation Products And Raw materials
Raw materials
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