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CAY10703

Product Name
CAY10703
CAS No.
1841421-67-7
Chemical Name
CAY10703
Synonyms
CAY10703;CAY10703,CAY-10703;Acetamide, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[2,2-dichloro-;N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(2,2-dichloroacetamide)
CBNumber
CB43152586
Molecular Formula
C12H18Cl6N4O3
Formula Weight
479.01
MOL File
1841421-67-7.mol
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CAY10703 Property

Boiling point:
680.0±55.0 °C(Predicted)
Density 
1.491±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
form 
A crystalline solid
pka
11.84±0.46(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18911
Product name
CAY10703
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18911
Product name
CAY10703
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
18911
Product name
CAY10703
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
18911
Product name
CAY10703
Purity
≥95%
Packaging
25mg
Price
$533
Updated
2024/03/01
AK Scientific
Product number
7562EH
Product name
N-[2-[Bis[2-[(2,2-dichloroacetyl)amino]ethyl]amino]ethyl]-2,2-dichloroacetamide
Packaging
10mg
Price
$370
Updated
2021/12/16
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CAY10703 Chemical Properties,Usage,Production

Description

Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria.1,2 Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases.2,3 CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA.4 It is approximately 3-fold less cytotoxic than DCA against peripheral blood mononuclear cells from healthy blood donors. CAY10703 significantly reduces both basal and maximal respiration in leukemia cells.4 It is stable in vivo after subcutaneous inoculation, remaining in circulation for more than five hours after injection.4

References

1. Whitehouse, S., Cooper, R.H., and Randle, P.J. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids Biochem. J. 141(3),761-774(1974).
2. Rodrigues, A.S., Correia, M., Gomes, A., et al. Dichloroacetate, the pyruvate dehydrogenase complex and the modulation of mESC pluripotency PLoS One 10(7),July 2015(2015).
3. Ruggieri, V., Agriesti, F., Scrima, R., et al. Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: A metabolic perspective of treatment Oncotarget 6(2),1217-1230(2015).
4. Trapella, C., Voltan, R., Melloni, E., et al. Design, synthesis, and biological characterization of novel mitochondria targeted dichloroacetate-loaded compounds with antileukemic activity J. Med. Chem. 59(1),147-156(2016).

CAY10703 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10703 Suppliers

China 8 United States 2 Global 10
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1841421-67-7, CAY10703Related Search:


  • CAY10703
  • CAY10703,CAY-10703
  • Acetamide, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[2,2-dichloro-
  • N,N',N''-(nitrilotris(ethane-2,1-diyl))tris(2,2-dichloroacetamide)
  • 1841421-67-7