ONO-8130

Product Name: ONO-8130
CAS No.: 459841-96-4
Chemical Name: ONO-8130
Synonyms: ONO-8130;4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid;Benzoic acid, 4-[[[2,3-dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-inden-5-yl]oxy]methyl]-;Orally active,ONO8130,Inhibitor,inhibit,Bladder pain,ONO 8130,Prostaglandin Receptor,Interstitial cystitis,PKR-like endoplasmic reticulum kinase,PERK,Hyperalgesia,Protein kinase R-like endoplasmic reticulum kinase,ONO-8130
CBNumber: CB43152708
Molecular Formula: C25H28N2O5S2
Formula Weight: 500.63
MOL File: 459841-96-4.mol

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ONO-8130 Property

Boiling point:: 705.1±70.0 °C(Predicted)
Density: 1.344±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤2mg/ml in ethanol;3mg/ml in DMSO;1mg/ml in dimethyl formamide
form: crystalline solid
pka: 4.17±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19118
Product name: ONO-8130
Purity: ≥98%
Packaging: 1mg
Price: $43
Updated: 2024/03/01

Cayman Chemical

Product number: 19118
Product name: ONO-8130
Purity: ≥98%
Packaging: 5mg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 19118
Product name: ONO-8130
Purity: ≥98%
Packaging: 10mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 19118
Product name: ONO-8130
Purity: ≥98%
Packaging: 25mg
Price: $621
Updated: 2024/03/01

Tocris

Product number: 5406
Product name: ONO8130
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1081
Updated: 2021/12/16

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ONO-8130 Chemical Properties,Usage,Production

Uses

ONO 8130 is a selective prostanoid EP1 receptor antagonist, which relieves bladder pain in mice with cyclophosphamide-induced cystitis.

Biological Activity

ono-8130 is an orally bioavailable and selective antagonist of the prostaglandin e2 (pge2) receptor ep1 with ki value of 1.9 nm [1][2][3].prostaglandins contribute to the sensitization of peripheral and central nociceptive neurons during peripheral inflammation. prostaglandin e2 (pge2) is considered a dominant pronociceptive prostanoid. pge2 receptors are g protein-coupled receptors and classified into 4 general subtypes (ep1, ep2, ep3, and ep4) that are located unevenly in different tissues. ep1 receptors play a major role in processing of pain [1].in cystitis-related bladder pain mice, oral preadministration of ono-8130 at 0.3-30 mg/kg strongly prevented both the bladder pain-like behavior and referred hyperalgesia in a dose-dependent way. ono-8130 at 30 mg/kg also reversed the established cystitis-related bladder pain. ono-8130 also blocked prostaglandin e2 caused prompt phosphorylation of erk in the l6 spinal cord [1]. in the guinea pig trachea (gpt), ono-8130 inhibited the initial contraction mediated by pge2. ono-8130 also eliminated the spontaneous tone [2].

storage

Store at +4°C

References

[1]. miki t, matsunami m, nakamura s, et al. ono-8130, a selective prostanoid ep1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. pain. 2011 jun;152(6):1373-81.
[2]. sfholm j, dahlén se, adner m. antagonising ep1 and ep2 receptors reveal that the tp receptor mediates a component of antigen-induced contraction of the guinea pig trachea. eur j pharmacol. 2013 oct 15;718(1-3):277-82.

ONO-8130 Preparation Products And Raw materials

Raw materials

Preparation Products

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ONO-8130 Suppliers

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459841-96-4, ONO-8130Related Search:

ONO-8130

4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid

Orally active,ONO8130,Inhibitor,inhibit,Bladder pain,ONO 8130,Prostaglandin Receptor,Interstitial cystitis,PKR-like endoplasmic reticulum kinase,PERK,Hyperalgesia,Protein kinase R-like endoplasmic reticulum kinase,ONO-8130

Benzoic acid, 4-[[[2,3-dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-inden-5-yl]oxy]methyl]-

459841-96-4