SR9238

Product Name: SR9238
CAS No.: 1416153-62-2
Chemical Name: SR9238
Synonyms: SR9238;SR9238 >=98% (HPLC);SR9238;SR-9238;SR 9238;Liver X receptor,SR-9238,SR 9238,LXR,SR9238,inhibit,Inhibitor;Ethyl 5-[[[4-(3-methylsulfonylphenyl)phenyl]methyl-(2,4,6-trimethylphenyl)sulfonylamino]methyl]furan-2-carboxylate;ethyl 5-{[N-({3'-methanesulfonyl-[1,1'-biphenyl]-4-yl}methyl)-2,4,6-trimethylbenzenesulfonamido]methyl}furan-2-carboxylate;Ethyl 5-((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate;Ethyl 5-(((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenyl)sulfonamido)methyl)furan-2-carboxylate;Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate;2-Furancarboxylic acid, 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-, ethyl ester
CBNumber: CB43152748
Molecular Formula: C31H33NO7S2
Formula Weight: 595.73
MOL File: 1416153-62-2.mol

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SR9238 Property

Boiling point:: 787.7±70.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 5 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 5 mg/ml
form: powder
pka: -10.53±0.70(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1510
Product name: SR9238
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1510
Product name: SR9238
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $424
Updated: 2023/06/20

Cayman Chemical

Product number: 18771
Product name: SR9238
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 18771
Product name: SR9238
Purity: ≥98%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 18771
Product name: SR9238
Purity: ≥98%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

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SR9238 Chemical Properties,Usage,Production

Uses

SR 9238 is an LXR inverse agonist, which also suppresses fibrosis in a model of non-alcoholic steatohepatitis.

Biochem/physiol Actions

SR9238 is liver selective LXR inverse agonist with high potency for both LXRα and LXRβ with an IC50 of 214 nM for LXRα and 43 nM for LXRβ. Metabolic syndrome is often accompanied by liver problems, such as fatty liver (nonalcoholic hepatosteatosis), associated with increased lipogenesis. Liver X receptors α and β (LXRα and LXRβ) are known to induce lipogenesis by increasing transcription of lipogenic enzyme genes, so it was hoped LXR antagonists might be of use in fatty liver. In a mouse model of nonalcoholic hepatosteatosis, SR9238 reduced the expression of lipogenic genes, and suppressed hepatic lipogenesis, inflammation and hepatic lipid accumulation. It was also effective in reduction of hepatic fibrosis in another study. Additionally in diet induced obese mice, SR9238 suppressed plasma cholesterol levels.

storage

Store at +4°C

SR9238 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR9238 Suppliers

China 43 India 1 United Kingdom 1 United States 6 USA 1 Global 52

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
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Email: info@chemlin.com.cn
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Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
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Sigma-Aldrich

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Taizhou Crene Biotechnology Co. Ltd.

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Email: sales@pharm-intermediates.com
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TargetMol Chemicals Inc.

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Country: United States
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InvivoChem

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Shanghai Dongyang Biotechnology Co., Ltd.

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1416153-62-2, SR9238Related Search:

2-AMINO-3-(4-CHLOROBENZOYL)-5,6,7,8-TETRAHYDROBENZOTHIOPHENE

SR9238

Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate

SR9238;SR-9238;SR 9238

2-Furancarboxylic acid, 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-, ethyl ester

SR9238 >=98% (HPLC)

Liver X receptor,SR-9238,SR 9238,LXR,SR9238,inhibit,Inhibitor

Ethyl 5-(((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenyl)sulfonamido)methyl)furan-2-carboxylate

Ethyl 5-((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate

ethyl 5-{[N-({3'-methanesulfonyl-[1,1'-biphenyl]-4-yl}methyl)-2,4,6-trimethylbenzenesulfonamido]methyl}furan-2-carboxylate

Ethyl 5-[[[4-(3-methylsulfonylphenyl)phenyl]methyl-(2,4,6-trimethylphenyl)sulfonylamino]methyl]furan-2-carboxylate

1416153-62-2

C31H33NO7S2

API