SR9238
- Product Name
- SR9238
- CAS No.
- 1416153-62-2
- Chemical Name
- SR9238
- Synonyms
- SR9238;SR9238 >=98% (HPLC);SR9238, 10 mM in DMSO;SR9238;SR-9238;SR 9238;Liver X receptor,SR-9238,SR 9238,LXR,SR9238,inhibit,Inhibitor;Ethyl 5-[[[4-(3-methylsulfonylphenyl)phenyl]methyl-(2,4,6-trimethylphenyl)sulfonylamino]methyl]furan-2-carboxylate;ethyl 5-{[N-({3'-methanesulfonyl-[1,1'-biphenyl]-4-yl}methyl)-2,4,6-trimethylbenzenesulfonamido]methyl}furan-2-carboxylate;Ethyl 5-((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate;Ethyl 5-(((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenyl)sulfonamido)methyl)furan-2-carboxylate;Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate
- CBNumber
- CB43152748
- Molecular Formula
- C31H33NO7S2
- Formula Weight
- 595.73
- MOL File
- 1416153-62-2.mol
SR9238 Property
- Boiling point:
- 787.7±70.0 °C(Predicted)
- Density
- 1.268±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 5 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 5 mg/ml
- form
- powder
- pka
- -10.53±0.70(Predicted)
- color
- white to beige
- InChIKey
- HDZWHJYZJWLTAG-UHFFFAOYSA-N
- SMILES
- [S](=O)(=O)(N(Cc4[o]c(cc4)C(=O)OCC)Cc2ccc(cc2)c3cc(ccc3)[S](=O)(=O)C)c1c(cc(cc1C)C)C
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- SML1510
- Product name
- SR9238
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $119
- Updated
- 2026/03/19
- Product number
- SML1510
- Product name
- SR9238
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $480
- Updated
- 2026/03/19
- Product number
- 18771
- Product name
- SR9238
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 18771
- Product name
- SR9238
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 18771
- Product name
- SR9238
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
SR9238 Chemical Properties,Usage,Production
Uses
SR 9238 is an LXR inverse agonist, which also suppresses fibrosis in a model of non-alcoholic steatohepatitis.
Biochem/physiol Actions
SR9238 is liver selective LXR inverse agonist with high potency for both LXRα and LXRβ with an IC50 of 214 nM for LXRα and 43 nM for LXRβ. Metabolic syndrome is often accompanied by liver problems, such as fatty liver (nonalcoholic hepatosteatosis), associated with increased lipogenesis. Liver X receptors α and β (LXRα and LXRβ) are known to induce lipogenesis by increasing transcription of lipogenic enzyme genes, so it was hoped LXR antagonists might be of use in fatty liver. In a mouse model of nonalcoholic hepatosteatosis, SR9238 reduced the expression of lipogenic genes, and suppressed hepatic lipogenesis, inflammation and hepatic lipid accumulation. It was also effective in reduction of hepatic fibrosis in another study. Additionally in diet induced obese mice, SR9238 suppressed plasma cholesterol levels.
in vivo
Approximately 6 μM SR9238 is detected in the liver 2h after the injection of SR9238, but no compound is detected in the plasma. SR9238 is also detected in the intestine with either ip or oral administration. SR9238-treated mice display greatly reduced lipid content in the liver. Results demonstrate that both Tnfa and Il1b expression are substantially reduced (~80% and >95%, respectively) in the SR9238-treated mice when compare to the vehicle-treated mice. SR9238-treated DIO mice display considerably lower intensity of F4/80 staining versus vehicle-treated DIO mice consistent with a beneficial effect of SR9238 on non-alcoholic steatohepatitis (NASH). SR9238 treatment does not alter body weight or percent body fat composition relative to vehicle treated animals during the experiment. Treatment with SR9238 suppresses diet-induced hepatosteatosis, hepatic inflammation, and hepatocellular injury[1].
storage
Store at +4°C
SR9238 Preparation Products And Raw materials
Raw materials
Preparation Products
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