ChemicalBook > CAS DataBase List > SR9238

SR9238

Product Name
SR9238
CAS No.
1416153-62-2
Chemical Name
SR9238
Synonyms
SR9238;SR9238 >=98% (HPLC);SR9238;SR-9238;SR 9238;Liver X receptor,SR-9238,SR 9238,LXR,SR9238,inhibit,Inhibitor;Ethyl 5-[[[4-(3-methylsulfonylphenyl)phenyl]methyl-(2,4,6-trimethylphenyl)sulfonylamino]methyl]furan-2-carboxylate;ethyl 5-{[N-({3'-methanesulfonyl-[1,1'-biphenyl]-4-yl}methyl)-2,4,6-trimethylbenzenesulfonamido]methyl}furan-2-carboxylate;Ethyl 5-((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate;Ethyl 5-(((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenyl)sulfonamido)methyl)furan-2-carboxylate;Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate;2-Furancarboxylic acid, 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-, ethyl ester
CBNumber
CB43152748
Molecular Formula
C31H33NO7S2
Formula Weight
595.73
MOL File
1416153-62-2.mol
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SR9238 Property

Boiling point:
787.7±70.0 °C(Predicted)
Density 
1.268±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 5 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 5 mg/ml
form 
powder
pka
-10.53±0.70(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1510
Product name
SR9238
Purity
≥98% (HPLC)
Packaging
5MG
Price
$105
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1510
Product name
SR9238
Purity
≥98% (HPLC)
Packaging
25MG
Price
$424
Updated
2023/06/20
Cayman Chemical
Product number
18771
Product name
SR9238
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
18771
Product name
SR9238
Purity
≥98%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
18771
Product name
SR9238
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
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SR9238 Chemical Properties,Usage,Production

Uses

SR 9238 is an LXR inverse agonist, which also suppresses fibrosis in a model of non-alcoholic steatohepatitis.

Biochem/physiol Actions

SR9238 is liver selective LXR inverse agonist with high potency for both LXRα and LXRβ with an IC50 of 214 nM for LXRα and 43 nM for LXRβ. Metabolic syndrome is often accompanied by liver problems, such as fatty liver (nonalcoholic hepatosteatosis), associated with increased lipogenesis. Liver X receptors α and β (LXRα and LXRβ) are known to induce lipogenesis by increasing transcription of lipogenic enzyme genes, so it was hoped LXR antagonists might be of use in fatty liver. In a mouse model of nonalcoholic hepatosteatosis, SR9238 reduced the expression of lipogenic genes, and suppressed hepatic lipogenesis, inflammation and hepatic lipid accumulation. It was also effective in reduction of hepatic fibrosis in another study. Additionally in diet induced obese mice, SR9238 suppressed plasma cholesterol levels.

storage

Store at +4°C

SR9238 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR9238 Suppliers

Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

1416153-62-2, SR9238Related Search:


  • SR9238
  • Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate
  • SR9238;SR-9238;SR 9238
  • 2-Furancarboxylic acid, 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-, ethyl ester
  • SR9238 >=98% (HPLC)
  • Liver X receptor,SR-9238,SR 9238,LXR,SR9238,inhibit,Inhibitor
  • Ethyl 5-(((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenyl)sulfonamido)methyl)furan-2-carboxylate
  • Ethyl 5-((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate
  • ethyl 5-{[N-({3'-methanesulfonyl-[1,1'-biphenyl]-4-yl}methyl)-2,4,6-trimethylbenzenesulfonamido]methyl}furan-2-carboxylate
  • Ethyl 5-[[[4-(3-methylsulfonylphenyl)phenyl]methyl-(2,4,6-trimethylphenyl)sulfonylamino]methyl]furan-2-carboxylate
  • 1416153-62-2
  • C31H33NO7S2
  • API