XLR11 N-(4-hydroxypentyl) metabolite (CRM) Property

Boiling point:

490.0±40.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

pka

13.88±0.20(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

XLR11 N-(4-hydroxypentyl) metabolite (CRM) Chemical Properties,Usage,Production

Description

XLR11 is a synthetic cannabinoid (CB) featuring a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB₂ receptor over the central CB₁ receptor.¹ XLR11 also has an N-(5-fluoropentyl) chain, which increases binding to both CB receptors.² XLR11 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of XLR11, based on the known metabolism of similar compounds.^3,4 The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications.

Uses

4-Hydroxypentyl XLR11 is a metabolite of XLR11 (X746300), an aminoalkylindole compound that is expected to be a cannabinoid (CB) mimetic.

Definition

ChEBI: XLR11 N-(4-hydroxypentyl) metabolite is a member of indoles.

References

1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB₂ cannabinoid receptor activity J. Med. Chem. 53(1),295-315(2010).
2. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives US7241799B2,(2001).
3. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB₂) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).
4. Wintermeyer, A., M?ller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010).