ASK1-IN-1
- Product Name
- ASK1-IN-1
- CAS No.
- 1262041-49-5
- Chemical Name
- ASK1-IN-1
- Synonyms
- CS-2713;ASK IN 1;GS-444217;ASK1-IN-1;ASK1-IN-110;ASK1-IN-1/GS-444217;GS-444217 (GS444217);GS-444217, 10 mM in DMSO;Apoptosis,inhibit,GS-444217,MAP kinase kinase kinase, MEKK, MAPKKK,MAP3K,Inhibitor;4-(4-cyclopropyl-1H-imidazol-1-yl)-N-(3-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)phenyl)picolinamide
- CBNumber
- CB43155057
- Molecular Formula
- C23H21N7O
- Formula Weight
- 411.46
- MOL File
- 1262041-49-5.mol
ASK1-IN-1 Property
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:37.75(Max Conc. mg/mL);91.74(Max Conc. mM)
- form
- Solid
- pka
- 11.20±0.70(Predicted)
- color
- White to off-white
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 40757
- Product name
- GS-444217
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $87
- Updated
- 2026/04/30
- Product number
- 40757
- Product name
- GS-444217
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2026/04/30
- Product number
- 40757
- Product name
- GS-444217
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $261
- Updated
- 2026/04/30
- Product number
- 40757
- Product name
- GS-444217
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $476
- Updated
- 2026/04/30
- Product number
- CS-6062
- Product name
- GS-444217
- Purity
- 99.80%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
ASK1-IN-1 Chemical Properties,Usage,Production
Uses
GS-444217 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM[1].
in vivo
GS-444217 reduces oxidative stress (OS)-induced ASK1 signaling in kidney and inhibits acute renal tubular injury in rats. GS-444217 (30 mg/kg) inhibits activation of ASK1, p38, and JNK in rat kidney. GS-444217 has an in vivo EC50 of approximately 1.6 μM for inhibiting the ASK1 pathway in rodent kidney[1].
References
[1] Liles JT, et al. ASK1 contributes to fibrosis and dysfunction in models of kidney disease. J Clin Invest. 2018 Oct 1;128(10):4485-4500. DOI:10.1172/JCI99768
[2] Budas GR, et al. ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2018 Feb 1;197(3):373-385. DOI:10.1164/rccm.201703-0502OC
ASK1-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
ASK1-IN-1 Suppliers
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