ChemicalBook > CAS DataBase List > IDO-IN-2

IDO-IN-2

Product Name: IDO-IN-2
CAS No.: 1668565-74-9
Chemical Name: IDO-IN-2
Synonyms: DO-IN-2;PCC0208009;IDO inhibitor 2;PCC0208009, 10 mM in DMSO;1-(4-(diisobutylamino)-2'-(1H-tetrazol-5-yl)biphenyl-3-yl)-3-p-tolylurea;1-(4-(Diisobutylamino)-2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)urea;Urea, N-[4-[bis(2-methylpropyl)amino]-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)-;PCC0208009,IDO,PCC-0208009,Inhibitor,Indoleamine 2,3-Dioxygenase (IDO),PCC 0208009,inhibit,neuropathic
CBNumber: CB43156650
Molecular Formula: C29H35N7O
Formula Weight: 497.63
MOL File: 1668565-74-9.mol

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IDO-IN-2 Property

Density: 1.206±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form: A solid
pka: 4.17±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6165
Product name: PCC0208009
Purity: 99.65%
Packaging: 2mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-6165
Product name: PCC0208009
Purity: 99.65%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-6165
Product name: PCC0208009
Purity: 99.65%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-6165
Product name: PCC0208009
Purity: 99.65%
Packaging: 50mg
Price: $590
Updated: 2021/12/16

DC Chemicals

Product number: DC10421
Product name: IDO-IN-2
Purity: >98%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

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IDO-IN-2 Chemical Properties,Usage,Production

Uses

PCC0208009 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala [1][2].

in vivo

PCC0208009 (single oral gavage; 50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 60, 120 and 240 min after drug administration in plasma and brain samples, and the highest concentrations of PCC0208009 in plasma and brain are observed at 60 min after administration. Concomitantly, the Kyn/Trp ratio decreases at 60, 120 and 240 min postdose, with the minimum level in the plasma and the brain seen at 60 min post-dose^[1].
PCC0208009 (oral gavage; once; 12-50 mg/kg) in adult male Sprague Dawley rats (180 g-200 g) is detected at 30, 60 and 90min after administration to evaluate the antinociceptive effects of PCC0208009 on neuropathic pain^[1].

Animal Model:	Adult male Sprague Dawley rats (180 g-200 g) ^[1]
Dosage:	50 mg/kg
Administration:	Single oral gavage
Result:	The highest concentrations of PCC0208009 in plasma and brain were observed at 60 min after administration.

Animal Model:	Adult male Sprague-Dawley rats bearing spinal nerve ligation (SNL)^[1]
Dosage:	12.5 mg/kg, 25 mg/kg, 50 mg/kg
Administration:	oral gavage; once
Result:	Showed the behavioral tests and the timelines.

IC 50

IDO: 4.52 nM (IC₅₀, in HeLa cell)

References

[1] Yu Wang, et al. PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala. Biochem Pharmacol. 2020 Jul;177:113926. DOI:10.1016/j.bcp.2020.113926
[2] David K Williams, et al. Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Bioorg Med Chem Lett. 2018 Feb 15;28(4):732-736. DOI:10.1016/j.bmcl.2018.01.010
[3] Shanyue Sun, et al. PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models. Int J Immunopathol Pharmacol. Jan-Dec 2018;32:2058738418787991. DOI:10.1177/2058738418787991

IDO-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from IDO-IN-2 manufacturers

Career Henan Chemical Co

Product: IDO-IN-2 1668565-74-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-29

1668565-74-9, IDO-IN-2Related Search:

DO-IN-2

IDO inhibitor 2

Urea, N-[4-[bis(2-methylpropyl)amino]-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)-

PCC0208009

PCC0208009,IDO,PCC-0208009,Inhibitor,Indoleamine 2,3-Dioxygenase (IDO),PCC 0208009,inhibit,neuropathic

1-(4-(diisobutylamino)-2'-(1H-tetrazol-5-yl)biphenyl-3-yl)-3-p-tolylurea

1-(4-(Diisobutylamino)-2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)urea

PCC0208009, 10 mM in DMSO

1668565-74-9

C29H35N7O