1-(2,4,5-Trihydroxyphenyl)ethanone

Product Name: 1-(2,4,5-Trihydroxyphenyl)ethanone
CAS No.: 1818-27-5
Chemical Name: 1-(2,4,5-Trihydroxyphenyl)ethanone
Synonyms: acetophenone, 2,4,5-trihydroxy;1-(2,4,5-Trihydroxyphenyl)ethanone;Ethanone, 1-(2,4,5-trihydroxyphenyl)-;1-(2,4,5-trihydroxyphenyl)ethan-1-one
CBNumber: CB43161931
Molecular Formula: C8H8O4
Formula Weight: 168.15
MOL File: 1818-27-5.mol

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1-(2,4,5-Trihydroxyphenyl)ethanone Property

Melting point:: 200-202 °C
Boiling point:: 404.3±30.0 °C(Predicted)
Density: 1.446±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 7.81±0.23(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0060848
Product name: 1-(2,4,5-Trihydroxyphenyl)ethanone
Packaging: 1g
Price: $124
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1012846
Product name: 1-(2,4,5-TRIHYDROXY-PHENYL)-ETHANONE
Purity: 95.00%
Packaging: 5MG
Price: $502.06
Updated: 2021/12/16

AK Scientific

Product number: 9379AH
Product name: 1-(2,4,5-Trihydroxy-phenyl)-ethanone
Packaging: 5g
Price: $863
Updated: 2021/12/16

ChemScene

Product number: CS-0060848
Product name: 1-(2,4,5-Trihydroxyphenyl)ethanone
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Ambeed

Product number: A171011
Product name: 1-(2,4,5-Trihydroxyphenyl)ethanone
Purity: 97%
Packaging: 100mg
Price: $58
Updated: 2021/12/16

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1-(2,4,5-Trihydroxyphenyl)ethanone Chemical Properties,Usage,Production

Preparation

Preparation by Fries rearrangement of 1,2,4-triacetoxy-benzene,
with aluminium chloride in nitrobenzene (30–43%)
with zinc chloride at 135–140° (49–53%)
with p-toluenesulfonic acid in refluxing tetrachloroethane or benzene or without solvent at 135–140° (60%).

Synthesis

66003-50-7

1818-27-5

General procedure for the synthesis of 1-(2,4,5-trihydroxyphenyl)ethan-1-one from 1-(6-hydroxybenzo[D][1,3]dioxolan-5-yl)ethan-1-one: The compound 1-(6-hydroxybenzo[D][1,3]dioxolan-5-yl)ethan-1-one (4 g, 19.03 mmol) was dissolved in chlorobenzene (20 mL) at room temperature, and in a Trichlorosilane (6.6 g, 49.47 mmol) was slowly added dropwise under nitrogen protection. The reaction mixture was heated to reflux for 24 hours. Upon completion of the reaction, the chlorobenzene was removed by rotary evaporation. The residue was dissolved in 1 M hydrochloric acid (50 mL) and extracted with ethyl acetate. The extract was post-treated and purified by silica gel column chromatography to afford 1-(2,4,5-trihydroxyphenyl)ethanone (2.1 g, 12.7 mmol) as a pale yellow solid in 66.9% yield.

References

[1] Patent: CN107935982, 2018, A. Location in patent: Paragraph 0023; 0024
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 13, p. 3872 - 3875

1-(2,4,5-Trihydroxyphenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(2,4,5-Trihydroxyphenyl)ethanone manufacturers

Career Henan Chemical Co

Product: 1-(2,4,5-Trihydroxyphenyl)ethanone 1818-27-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

1818-27-5, 1-(2,4,5-Trihydroxyphenyl)ethanoneRelated Search:

1-(2,4,5-Trihydroxyphenyl)ethanone

1-(2,4,5-trihydroxyphenyl)ethan-1-one

acetophenone, 2,4,5-trihydroxy

Ethanone, 1-(2,4,5-trihydroxyphenyl)-

1818-27-5