Mal-PEG1-Bromide
- Product Name
- Mal-PEG1-Bromide
- CAS No.
- 1823885-81-9
- Chemical Name
- Mal-PEG1-Bromide
- Synonyms
- Mal-PEG1-Bromide;1-(2-(2-bromoethoxy)ethyl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-[2-(2-bromoethoxy)ethyl]-;1-[2-(2-bromoethoxy)ethyl]-2,5-dihydro-1H-pyrrole-2,5-dione
- CBNumber
- CB43162983
- Molecular Formula
- C8H10BrNO3
- Formula Weight
- 248.07
- MOL File
- 1823885-81-9.mol
Mal-PEG1-Bromide Property
- Boiling point:
- 358.1±22.0 °C(Predicted)
- Density
- 1.588±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- -2.35±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-22139
- Product name
- Mal-PEG1-Bromide
- Purity
- 98%
- Packaging
- 500mg
- Price
- $560
- Updated
- 2021/12/16
- Product number
- BIPG1501
- Product name
- Mal-PEG1-Bromide
- Packaging
- 250mg
- Price
- $701
- Updated
- 2021/12/16
Mal-PEG1-Bromide Chemical Properties,Usage,Production
Description
Mal-PEG1-Bromide contains a maleimide group and bromide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions.
Uses
Mal-PEG1-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Mal-PEG1-Bromide Preparation Products And Raw materials
Raw materials
Preparation Products
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