tert-butyl (S)-(6-oxotetrahydro-2H-pyran-3-yl)carbamate

Product Name: tert-butyl (S)-(6-oxotetrahydro-2H-pyran-3-yl)carbamate
CAS No.: 125982-23-2
Chemical Name: tert-butyl (S)-(6-oxotetrahydro-2H-pyran-3-yl)carbamate
Synonyms: tert-butyl N-(6-oxooxan-3-yl)carbamate;(S)-5-(Boc-amino)tetrahydropyran-2-one;tert-butyl N-[(3S)-6-oxotetrahydropyran-3-yl]carbamate;(S)-tert-Butyl (6-oxotetrahydro-2H-pyran-3-yl)carbamate;tert-butyl (S)-(6-oxotetrahydro-2H-pyran-3-yl)carbamate;Carbamic acid, N-[(3S)-tetrahydro-6-oxo-2H-pyran-3-yl]-, 1,1-dimethylethyl ester
CBNumber: CB43163672
Molecular Formula: C10H17NO4
Formula Weight: 215.25
MOL File: 125982-23-2.mol

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tert-butyl (S)-(6-oxotetrahydro-2H-pyran-3-yl)carbamate Property

storage temp.: 2-8°C
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 3098CV
Product name: CID14409468
Packaging: 1g
Price: $168
Updated: 2021/12/16

Crysdot

Product number: CD00011489
Product name: (S)-tert-Butyl(6-oxotetrahydro-2H-pyran-3-yl)carbamate
Purity: 97%
Packaging: 5g
Price: $317
Updated: 2021/12/16

Ambeed

Product number: A539440
Product name: (S)-tert-Butyl(6-oxotetrahydro-2H-pyran-3-yl)carbamate
Purity: 97%
Packaging: 5g
Price: $320
Updated: 2021/12/16

Crysdot

Product number: CD00011489
Product name: (S)-tert-Butyl(6-oxotetrahydro-2H-pyran-3-yl)carbamate
Purity: 97%
Packaging: 10g
Price: $594
Updated: 2021/12/16

Ambeed

Product number: A539440
Product name: (S)-tert-Butyl(6-oxotetrahydro-2H-pyran-3-yl)carbamate
Purity: 97%
Packaging: 10g
Price: $600
Updated: 2021/12/16

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tert-butyl (S)-(6-oxotetrahydro-2H-pyran-3-yl)carbamate Chemical Properties,Usage,Production

Synthesis

126587-35-7

125982-23-2

Methyl (S)-4-((tert-butoxycarbonyl)amino)-5-hydroxypentanoate (25 g, 0.1 mol, 1.0 eq.) was used as a raw material, which was dissolved in a mixed solvent of toluene (300 mL) and acetic acid (150 mL), and the reaction was heated and refluxed for 5 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was placed in an ice bath and the pH was adjusted to 7-8 by slowly adding saturated sodium bicarbonate solution. the aqueous phase was extracted three times with ethyl acetate, and the organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated to give the crude product. The crude product was purified by solvent recrystallization with mixed solvents of ethyl acetate and petroleum ether to afford the target product tert-butyl (S)-(6-oxotetrahydro-2H-pyran-3-yl)carbamate (8.0 g, 37.2% yield) as a white powder. The product was analyzed by GC-MS and the molecular ion peak was 215.

References

[1] Tetrahedron Letters, 1989, vol. 30, # 29, p. 3803 - 3804
[2] Journal of Organic Chemistry, 1991, vol. 56, # 13, p. 4167 - 4176
[3] Patent: WO2018/67422, 2018, A1. Location in patent: Page/Page column 47; 48
[4] Patent: WO2015/168246, 2015, A1. Location in patent: Page/Page column 64; 75

tert-butyl (S)-(6-oxotetrahydro-2H-pyran-3-yl)carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl (S)-(6-oxotetrahydro-2H-pyran-3-yl)carbamate Suppliers

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