ChemicalBook > CAS DataBase List > 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]

2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]

Product Name
2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]
CAS No.
1268273-90-0
Chemical Name
2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]
Synonyms
HSP70-IN-1;HSP70-IN-27c;HSP70 inhibitor 1;HSP70-IN-1( LUN-00465);HSP70-IN-1, 10 mM in DMSO;HSP70 IN 1,inhibit,HSP-70-IN-1,Heat shock proteins,Inhibitor,HSP70IN1,HSP;2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl];Acetamide, 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]-;N-(3-{[4-(Benzyloxy)-2-(4-methyl-1-piperazinyl)-5-pyrimidinyl]sulfanyl}phenyl)glycinamide hydrochloride
CBNumber
CB43166002
Molecular Formula
C24H28N6O2S
Formula Weight
464.58
MOL File
1268273-90-0.mol
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2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl] Property

Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 50 mg/mL (107.62 mM)
form 
Solid
pka
13.27±0.70(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6368
Product name
HSP70-IN-1
Purity
98.01%
Packaging
1mg
Price
$132
Updated
2021/12/16
ChemScene
Product number
CS-6368
Product name
HSP70-IN-1
Purity
98.01%
Packaging
5mg
Price
$396
Updated
2021/12/16
ChemScene
Product number
CS-6368
Product name
HSP70-IN-1
Purity
98.01%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-6368
Product name
HSP70-IN-1
Purity
98.01%
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-6368
Product name
HSP70-IN-1
Purity
98.01%
Packaging
100mg
Price
$2520
Updated
2021/12/16
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2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl] Chemical Properties,Usage,Production

Uses

HSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.

IC 50

HSP70; Caspase-3/7: 1.9 μM (IC50, MOLM13 cells)

References

[1] Taldone T, et al. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. J Med Chem. 2014 Feb 27;57(4):1208-24. DOI:10.1021/jm401552y

2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl] Preparation Products And Raw materials

Raw materials

Preparation Products

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2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl] Suppliers

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View Lastest Price from 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl] manufacturers

Career Henan Chemical Co
Product
2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl] 1268273-90-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23
Career Henan Chemical Co
Product
2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl] 1268273-90-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

1268273-90-0, 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]Related Search:


  • HSP70-IN-1
  • 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]
  • N-(3-{[4-(Benzyloxy)-2-(4-methyl-1-piperazinyl)-5-pyrimidinyl]sulfanyl}phenyl)glycinamide hydrochloride
  • HSP70-IN-27c
  • HSP70 inhibitor 1
  • Acetamide, 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]-
  • HSP70-IN-1( LUN-00465)
  • HSP70 IN 1,inhibit,HSP-70-IN-1,Heat shock proteins,Inhibitor,HSP70IN1,HSP
  • HSP70-IN-1, 10 mM in DMSO
  • 1268273-90-0
  • API