ChemicalBook > CAS DataBase List > JJKK 048

JJKK 048

Product Name
JJKK 048
CAS No.
1515855-97-6
Chemical Name
JJKK 048
Synonyms
JJKK 048;JJKK-048 >=98% (HPLC);JJKK 048, 10 mM in DMSO;inhibit,JJKK-048,JJKK048,MAGL,Inhibitor,Monoacylglycerol lipase,JJKK 048;4-[Bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-methanone;Methanone, [4-[bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-;(4-(Bis(benzo[d][1,3]dioxol-5-yl)methyl)piperidin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
CBNumber
CB43167160
Molecular Formula
C23H22N4O5
Formula Weight
434.44
MOL File
1515855-97-6.mol
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JJKK 048 Property

Boiling point:
615.9±65.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble to 100 mM in DMSO
form 
Powder
pka
1.70±0.10(Predicted)
color 
White to off-white
InChI
1S/C23H22N4O5/c28-23(27-12-24-11-25-27)26-7-5-15(6-8-26)22(16-1-3-18-20(9-16)31-13-29-18)17-2-4-19-21(10-17)32-14-30-19/h1-4,9-12,15,22H,5-8,13-14H2
InChIKey
CLSNATLUIXZPMV-UHFFFAOYSA-N
SMILES
O=C(N1N=CN=C1)N2CCC(C(C3=CC(OCO4)=C4C=C3)C5=CC=C(OCO6)C6=C5)CC2
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1830
Product name
JJKK-048
Purity
≥98% (HPLC)
Packaging
5MG
Price
$125
Updated
2026/04/30
Sigma-Aldrich
Product number
SML1830
Product name
JJKK-048
Purity
≥98% (HPLC)
Packaging
25MG
Price
$511
Updated
2026/04/30
Tocris
Product number
5206
Product name
JJKK048
Purity
≥98%(HPLC)
Packaging
10
Price
$219
Updated
2021/12/16
TRC
Product number
J212008
Product name
JJKK048
Packaging
2.5mg
Price
$195
Updated
2021/12/16
Usbiological
Product number
255553
Product name
JJKK 048
Packaging
10mg
Price
$475
Updated
2021/12/16
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JJKK 048 Chemical Properties,Usage,Production

Uses

JJKK 048 inhibits monoacylglycerol lipase by terminating signaling pathway of 2-arachidonoylglycerol in mouse brain and human melanoma cell proteome. JJKK 048 can be classified as a MAGL inhibitor that has therapeutic potential for the treatment of cancers.

Biological Activity

JJKK-048 is a cell penetrant ultrapotent and highly selective inhibitor of monoacylglycerol lipase (MAGL) th at exhibits a low cross-reactivity with other endocannabinoid targets. JJKK-048 is an irreversible inhibitor th at binds to the active site S122.

in vivo

JJKK 048 (0.1-4 mg/kg; i.p.; single dose; acute administration) potently inhibits MAGL and elevates brain 2-Arachidonoylglycerol (2-AG) (HY-W011051) levels in male C57Bl/6J mice[2].
JJKK 048 (0.5-2 mg/kg; i.p.; single dose; acute administration) inhibits MAGL in peripheral tissues (liver, spleen, heart, and skeletal muscle) with some off - target effects in mouse[2].
JJKK 048 (0.5 mg/kg; i.p.; single dose; acute administration) promotes significant analgesia in a writhing test in male Albino Swiss mice without causing cannabimimetic side effects[2].
JJKK 048 (1-2 mg/kg; i.p.; single dose; acute administration) induces analgesia both in the writhing test and in the tail - immersion test, as well as hypomotility and hyperthermia, but not catalepsy in male Albino Swiss mice[2].

Animal Model:Male C57Bl/6J mice (8 weeks old, weight 20-26 g)[2]
Dosage:0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg, (dissolved in 5% (v/v) dimethylsulfoxide (DMSO) in gently heated 10% (w/v) HP-β-CD (HY-101103))
Administration:i.p., single dose
Result:Revealed a dose-dependent blockade of MAGL in the brain.
Increased brain 2-AG levels in a dose-dependent manner, while brain AEA levels remained unaffected.
Animal Model:Male Albino Swiss mice (weight 20-30 g), tetrad test model for cannabimimetic effects[2]
Dosage:0.5 mg/kg, 1 mg/kg, 2 mg/kg (dissolved in 5% (v/v) DMSO in gently heated 10% (w/v) HP-β-CD (HY-101103))
Administration:i.p., single dose
Result:Caused significant reduction in the writhing episodes of mice in the writhing test, indicating an antinociceptive effect.

storage

Store at -20°C

JJKK 048 Preparation Products And Raw materials

Raw materials

Preparation Products

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JJKK 048 Suppliers

China 40 United Kingdom 1 United States 5 Global 46
Adamas Reagent, Ltd.
Tel
400-6009262 15618770481
Fax
021-64823266
Email
yhx@titansci.com
Country
China
ProdList
14100
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59
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
89689
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60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
9697
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
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Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3290
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44896
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58

1515855-97-6, JJKK 048Related Search:


  • JJKK 048
  • 4-[Bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-methanone
  • Methanone, [4-[bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-
  • JJKK-048 >=98% (HPLC)
  • (4-(Bis(benzo[d][1,3]dioxol-5-yl)methyl)piperidin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
  • inhibit,JJKK-048,JJKK048,MAGL,Inhibitor,Monoacylglycerol lipase,JJKK 048
  • JJKK 048, 10 mM in DMSO
  • 1515855-97-6