ChemicalBook > CAS DataBase List > TLR2-IN-C29

TLR2-IN-C29

Product Name
TLR2-IN-C29
CAS No.
363600-92-4
Chemical Name
TLR2-IN-C29
Synonyms
R2-IN-C29;TLR2-IN-C29;C29;C 29;C-29;C29, 10 mM in DMSO;TLR2-IN-C29 (C29 );3-((2-Hydroxy-3-methoxybenzylidene)amino)-2-methylbenzoic acid;Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-;C29,TLR2,Inhibitor,hTLR2/1,inhibit,C-29,Toll-like,Toll-like Receptor (TLR),hTLR2/6,C 29
CBNumber
CB43168697
Molecular Formula
C16H15NO4
Formula Weight
285.29
MOL File
363600-92-4.mol
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TLR2-IN-C29 Property

Melting point:
>192°C (dec.)
Boiling point:
505.7±50.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.01±0.10(Predicted)
color 
Dark Orange
Stability:
Moisture Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27029
Product name
C29
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
27029
Product name
C29
Packaging
25mg
Price
$745
Updated
2024/03/01
Cayman Chemical
Product number
27029
Product name
C29
Packaging
5mg
Price
$194
Updated
2024/03/01
Cayman Chemical
Product number
27029
Product name
C29
Packaging
10mg
Price
$357
Updated
2024/03/01
TRC
Product number
T426518
Product name
TLR2-IN-C29
Packaging
2.5mg
Price
$150
Updated
2021/12/16
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TLR2-IN-C29 Chemical Properties,Usage,Production

Uses

TLR2-IN-29 is a inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.

Biological Activity

TLR2-IN-C29 is a toll/IL-1 receptor resistance (TIR) domain BB loop-targeting, selective toll-like receptor 2 (TLR2) antagonist th at inhibits both human TLR2/1 and TLR2/6-mediated signaling (IC50 = 37.6/19.7 μM against 50 ng/mL Pam3CSK/Pam2CSK-induced reporter signal, respectively, using HEK293T TLR2/6 or TLR2/1 transfectants), while blocking only murine TLR2/1-, but not murine TLR2/6-, mediated signaling (1h 25-50 μM C29 treatment prior to 50 ng P3C/mL or 100 ng P2C/mL for 1h in murine macrophages), nor signaling induced by other TLR agonists and TNF-α.

TLR2-IN-C29 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TLR2-IN-C29 manufacturers

Career Henan Chemical Co
Product
TLR2-IN-C29 363600-92-4
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

363600-92-4, TLR2-IN-C29Related Search:


  • C29;C 29;C-29
  • TLR2-IN-C29
  • R2-IN-C29
  • Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-
  • 3-((2-Hydroxy-3-methoxybenzylidene)amino)-2-methylbenzoic acid
  • TLR2-IN-C29 (C29 )
  • C29,TLR2,Inhibitor,hTLR2/1,inhibit,C-29,Toll-like,Toll-like Receptor (TLR),hTLR2/6,C 29
  • C29, 10 mM in DMSO
  • 363600-92-4