EC330

Product Name: EC330
CAS No.: 2016795-77-8
Chemical Name: EC330
Synonyms: EC330;EC-330; EC 330;EC-330,EC 330,EC330,inhibit,Inhibitor;Estra-4,9-dien-3-one, 11-(4-cyclopropylphenyl)-17-(1,1-difluoro-2-propyn-1-yl)-17-hydroxy-, (11β,17β)-;(8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
CBNumber: CB43171691
Molecular Formula: C30H32F2O2
Formula Weight: 462.57
MOL File: 2016795-77-8.mol

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EC330 Property

Boiling point:: 623.4±55.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 20 mg/mL (43.24 mM)
pka: 12.90±0.60(Predicted)

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Safety

HS Code: 2914409000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Apolloscientific

Product number: BISN0077
Product name: EC330
Purity: 98%
Packaging: 1mg
Price: $254
Updated: 2021/12/16

Apolloscientific

Product number: BISN0077
Product name: EC330
Purity: 98%
Packaging: 5mg
Price: $544
Updated: 2021/12/16

Apolloscientific

Product number: BISN0077
Product name: EC330
Purity: 98%
Packaging: 10mg
Price: $798
Updated: 2021/12/16

DC Chemicals

Product number: DC10277
Product name: EC330
Purity: >98%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

DC Chemicals

Product number: DC10277
Product name: EC330
Purity: >98%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

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EC330 Chemical Properties,Usage,Production

Description

EC330 is used as potential LIF inhibitors. The remaining EC330-like inhibitors include EC357, and EC363. They were designed based on the structure–activity relationship (SAR) studies on human breast cancer MCF7 cells with LIF overexpression. The SAR established through this screening includes following criteria: (i) the steroidal skeleton of the molecule is an antiprogestin, (ii) the molecule has the specific 17α-difluoro acetylenic moiety, and (iii) nonpolar substituents at position 11 are preferred over polar substituents. EC330, EC357, and EC363 have all these features. EC330 inhibits the LIF/LIF-R signaling and blocks the promoting effects of LIF on growth and migration of cancer cells.[1].

in vitro

EC330 shows marked specificity in MCF-7 cells overexpressing LIF verses MCF-7 cells. EC330 further shows cytoskeletal disruption and targeting cancer-associated fibroblasts (CAFs) through inhibition of alpha-SMA but not beta-tubulin.

in vivo

EC330 treatment (0.1, 0.5 and 2.5 mg/kg) dose dependently reduces tumor burden in ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cell xenografted mouse models as well as MDA-MB-231 PDX models. EC330 exhibits no reactivity towards thiol-cysteine residues, no off target binding to major receptors, kinases or ion channels. EC330 is orally bioavailable and found to be safe and tolerable in toxicity studies.

EC330 Preparation Products And Raw materials

Raw materials

Preparation Products

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EC330 Suppliers

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2016795-77-8, EC330Related Search:

EC330

EC-330; EC 330

Estra-4,9-dien-3-one, 11-(4-cyclopropylphenyl)-17-(1,1-difluoro-2-propyn-1-yl)-17-hydroxy-, (11β,17β)-

EC-330,EC 330,EC330,inhibit,Inhibitor

(8S,11R,13S,14S,17S)-11-(4-Cyclopropylphenyl)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

2016795-77-8

C30H32F2O2