EBELACTONE A

Product Name: EBELACTONE A
CAS No.: 76808-16-7
Chemical Name: EBELACTONE A
Synonyms: Nsc 335650;Ebelactone;EBELACTONE A;ebelactone a microbial;Ebelactone A microbial esterase inhibitor;4-beta(1r*,3e,5s*,7r*,8s*,9s*)))-3s-(3-alph;3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECEN-3-OLIDE;3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC 1,3-LACTONE;3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECANOIC-1,3-LACTONE;3,11-DIHYDROXY-2,4,5,6,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC 1,3-LACTONE
CBNumber: CB4319218
Molecular Formula: C20H34O4
Formula Weight: 338.48
MOL File: 76808-16-7.mol

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EBELACTONE A Property

storage temp.: 2-8°C
solubility: DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml
form: White crystalline powder.
biological source: Streptomyces sp.

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Safety

WGK Germany: 3
RTECS: RQ7730000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E0761
Product name: Ebelactone A microbial
Purity: esterase inhibitor
Packaging: 1mg
Price: $364
Updated: 2025/07/31

Cayman Chemical

Product number: 19163
Product name: Ebelactone A
Purity: ≥98%
Packaging: 500μg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 19163
Product name: Ebelactone A
Purity: ≥98%
Packaging: 1mg
Price: $96
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: INB0000991
Product name: EBELACTONE A MICROBIAL
Purity: 95.00%
Packaging: 1MG
Price: $783.44
Updated: 2021/12/16

AHH

Product number: MT-11643
Product name: EbelactoneA
Purity: 99%
Packaging: 0.005g
Price: $298
Updated: 2021/12/16

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EBELACTONE A Chemical Properties,Usage,Production

Description

Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC₅₀s = 0.056, 0.003, and 0.08 μg/ml, respectively) found on cell surfaces, which has been shown to stimulate host defense in immune cells. Ebelactone A is also reported to inhibit cutinases produced by fungal pathogens, thus demonstrating a plant-protective function.

Uses

Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively[1]. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis[2].

References

[1] Umezawa H, et al., Ebelactone, an inhibitor of esterase, produced by actinomycetes. J Antibiot (Tokyo). 1980 Dec;33(12):1594-6. DOI:10.7164/antibiotics.33.1594
[2] Francis S A, et al., The role of cutinase in germling development and infection byErysiphe graminisf. sp. hordei[J]. Physiological and Molecular Plant Pathology, 1996, 49(3): 201-211.

EBELACTONE A Preparation Products And Raw materials

Raw materials

Preparation Products

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EBELACTONE A Suppliers

China 20 Germany 2 Japan 1 Switzerland 2 United States 10 Global 35

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 18679456698
Email: mingxinzhu@huidabiotech.com
Country: China
ProdList: 2975
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

76808-16-7, EBELACTONE ARelated Search:

EBELACTONE B (2-ETHYL-3,11-D 2,4-DIMETHYL-3-HEPTANONE 6-METHYL-6-HEPTENOIC ACID TRANS-5-DECEN-1-OL 2,4-Dimethyl-3-pentanone 6-decenoic acid 2,4-DIMETHYL-3-HEXANONE 2-Oxetanone TRIMETHYLENE OXIDE 3,5-DIMETHYL-3-HEPTENE BETA-BUTYROLACTONE 2,4,6-TRIMETHYL-3-HEPTENE (CIS)-8-METHYLNON-6-ENOIC ACID EBELACTONE B,ebelactone b microbial EBELACTONE A

4-(8-hydroxy-1,3,5,7,9-pentamethyl-6-oxo-3-undecenyl)-3-methyl-2-oxetanon(

4-beta(1r*,3e,5s*,7r*,8s*,9s*)))-3s-(3-alph

EBELACTONE A

3,11-DIHYDROXY-2,4,5,6,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC 1,3-LACTONE

3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECANOIC-1,3-LACTONE

3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECEN-3-OLIDE

3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC 1,3-LACTONE

3,11-DIHYDROXY-2,4,6,8,10,12-HEXAMETHYL-9-OXO-6-TETRADECENOIC ACID 1,3-LACTONE

ebelactone a microbial

(3S)-4α-[(1S,3E,5R,7S,8R,9R)-8-Hydroxy-1,3,5,7,9-pentamethyl-6-oxo-3-undecenyl]-3β-methyloxetan-2-one

2-Oxetanone, 4-(8-hydroxy-1,3,5,7,9-pentamethyl-6-oxo-3-undecenyl)-3-methyl-, (3S-(3-alpha,4-beta(1R*,3E,5S*,7R*,8S*,9S*)))-

Nsc 335650

2-Oxetanone, 4-[(1S,3E,5R,7S,8R,9R)-8-hydroxy-1,3,5,7,9-pentamethyl-6-oxo-3-undecen-1-yl]-3-methyl-, (3S,4S)-

Ebelactone A microbial esterase inhibitor

Ebelactone

76808-16-7

BioChemical

Biochemicals and Reagents

Esterase, lipase and N-formylmethionine aminopeptidase

Enzyme Inhibitors

D to K

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme