5-Acetyloxindole
- Product Name
- 5-Acetyloxindole
- CAS No.
- 64483-69-8
- Chemical Name
- 5-Acetyloxindole
- Synonyms
- 5-ACETYLOXINDOLE;1H-indol-5-yl acetate;5-acetyl-2-indolinone;5-acetylindolin-2-one;5-Acetyl-1H-indolin-2-one;5-Acetyl-1,3-dihydro-indol-2-one;2H-Indol-2-one,5-acetyl-1,3-dihydro-
- CBNumber
- CB4325127
- Molecular Formula
- C10H9NO2
- Formula Weight
- 175.18
- MOL File
- 64483-69-8.mol
5-Acetyloxindole Property
- Melting point:
- 225-227 °C
- Boiling point:
- 418.4±45.0 °C(Predicted)
- Density
- 1.228±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.46±0.20(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 64483-69-8(CAS DataBase Reference)
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- A165425
- Product name
- 5-Acetyloxindole
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA149735
- Product name
- 5-Acetyloxindole
- Packaging
- 1g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- FA149735
- Product name
- 5-Acetyloxindole
- Packaging
- 2g
- Price
- $127
- Updated
- 2021/12/16
- Product number
- OR913281
- Product name
- 5-Acetyloxindole
- Purity
- 95%
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FA149735
- Product name
- 5-Acetyloxindole
- Packaging
- 5G
- Price
- $254
- Updated
- 2021/12/16
5-Acetyloxindole Chemical Properties,Usage,Production
Synthesis
59-48-3
75-36-5
64483-69-8
Example I Synthesis of 5-acetyl-2-indolomanone: 171 g (1.28 mol) of anhydrous aluminum chloride was suspended in 500 mL of 1,2-dichloroethane and cooled to 0-5°C under ice bath conditions. Subsequently, 78 g (1.1 mol) of acetyl chloride was slowly added dropwise, and the reaction temperature was controlled to not exceed 10 °C. After the dropwise addition, the reaction was continued with stirring for 1 hour. Then, 71.3 g (0.53 mol) of 2-indolone (1,3-dihydroindol-2-one) was added in four batches, ensuring that the reaction temperature was maintained between 10-12 °C after each batch. After the addition was completed, the reaction mixture was allowed to warm slowly to room temperature and stirred overnight. At the end of the reaction, the reaction solution was quenched by slowly pouring it into 1 kg of ice water under vigorous stirring. Subsequently, the slurry was diluted with 1 L of water and stirring was continued for 30 min. The precipitate was collected by diafiltration and dried to give the crude product. After purification, 80.9 g of the target compound 5-acetyl-2-indolomanone was obtained in 86.3% yield of the theoretical value. Thin layer chromatography (TLC) analysis showed Rf = 0.36 (silica gel plate, unfolding agent was ethyl acetate/cyclohexane/methanol = 9:9:2). The molecular formula of the product was C10H9NO2 (molecular weight = 175.19 g/mol) and mass spectrometry analysis showed m/z = 174 ([M-H]-).
References
[1] Patent: US2005/203104, 2005, A1. Location in patent: Page/Page column 8
[2] Patent: WO2005/87726, 2005, A1. Location in patent: Page/Page column 22
[3] Patent: US2005/234120, 2005, A1. Location in patent: Page/Page column 7
[4] Patent: US2009/42876, 2009, A1. Location in patent: Page/Page column 25
[5] Patent: US6395734, 2002, B1
5-Acetyloxindole Preparation Products And Raw materials
Raw materials
Preparation Products
5-Acetyloxindole Suppliers
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 42446
- Advantage
- 60
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 13817873692
- Fax
- 021-31329586
- mkt@boynerspharm.com
- Country
- China
- ProdList
- 1707
- Advantage
- 55
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- sales@chemwill.com
- Country
- China
- ProdList
- 1974
- Advantage
- 58
- Tel
- 526763801 13301653310
- Fax
- +86-21-51619052
- 526763801@qq.com
- Country
- China
- ProdList
- 9273
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60