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1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-

Product Name
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
CAS No.
116409-29-1
Chemical Name
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
Synonyms
NSC 370284;NSC 370284, 10 mM in DMSO;1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
CBNumber
CB43282867
Molecular Formula
C21H25NO6
Formula Weight
387.43
MOL File
116409-29-1.mol
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1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Property

form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Chemical Properties,Usage,Production

Uses

NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5[1].

in vivo

NSC-370284 (2.5 mg/kg; i.p., once daily for 10 days) improves the pathological morphologies in peripheral blood (PB), bone marrow (BM), spleen, and liver tissues in MLL-AF9 acute myeloid leukemia (AML) mice model[1].

Animal Model:C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice[1].
Dosage:2.5?mg/kg.
Administration:Intraperitoneal injection, once daily, for 10 days.
Result:Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice.

IC 50

STAT3; STAT5; TET1

References

[1] Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099. DOI:10.1038/s41467-017-02290-w

1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Suppliers

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116409-29-1, 1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-Related Search:


  • 1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
  • NSC 370284
  • NSC 370284, 10 mM in DMSO
  • 116409-29-1