ChemicalBook > CAS DataBase List > 1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
- Product Name
- 1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
- CAS No.
- 116409-29-1
- Chemical Name
- 1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
- Synonyms
- NSC 370284;NSC 370284, 10 mM in DMSO;1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]-
- CBNumber
- CB43282867
- Molecular Formula
- C21H25NO6
- Formula Weight
- 387.43
- MOL File
- 116409-29-1.mol
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1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Property
- form
- Solid
- color
- Off-white to light yellow
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1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Chemical Properties,Usage,Production
Uses
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5[1].
in vivo
NSC-370284 (2.5 mg/kg; i.p., once daily for 10 days) improves the pathological morphologies in peripheral blood (PB), bone marrow (BM), spleen, and liver tissues in MLL-AF9 acute myeloid leukemia (AML) mice model[1].
| Animal Model: | C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice[1]. |
| Dosage: | 2.5?mg/kg. |
| Administration: | Intraperitoneal injection, once daily, for 10 days. |
| Result: | Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice. |
IC 50
STAT3; STAT5; TET1
References
[1] Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099. DOI:10.1038/s41467-017-02290-w
1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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1,3-Benzodioxol-5-ol,6-[1-pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl]- Suppliers
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