Fmoc-cycloleucine
- Product Name
- Fmoc-cycloleucine
- CAS No.
- 117322-30-2
- Chemical Name
- Fmoc-cycloleucine
- Synonyms
- FMOC-CLE-OH;FMOC-AC5C-OH;Fmoc-cLeu-OH;CAS:117322-30-2;FMOC-CYCLOLEUCINE;FMOC-NH(1)CPEN-OH;1-(Fmoc-amino)cycL;RARECHEM EM WB 0031;Fmoc-DL-cycloleucine;Fmoc-cycloleucine USP/EP/BP
- CBNumber
- CB4329145
- Molecular Formula
- C21H21NO4
- Formula Weight
- 351.4
- MOL File
- 117322-30-2.mol
Fmoc-cycloleucine Property
- Melting point:
- 187 °C(dec.)
- Boiling point:
- 579.4±29.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- soluble in Dimethylformamide
- form
- powder to crystal
- pka
- 4.08±0.20(Predicted)
- color
- White to Light yellow
- BRN
- 5995036
- CAS DataBase Reference
- 117322-30-2(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H402Harmful to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F0866
- Product name
- 1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclopentanecarboxylic Acid
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $91
- Updated
- 2025/07/31
- Product number
- F0866
- Product name
- 1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclopentanecarboxylic Acid
- Purity
- >95.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $272
- Updated
- 2025/07/31
- Product number
- F628023
- Product name
- Fmoc-Cycloleucine
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 450447
- Product name
- Fmoc-Cycloleucine
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- J97950
- Product name
- Fmoc-DL-cycloleucine
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
Fmoc-cycloleucine Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
Fmoc-cycloleucine is a reagent in the development of selective inhibitors of nuclear hormone receptors.
Synthesis
82911-69-1
52-52-8
117322-30-2
General procedure for the synthesis of Fmoc-cycloleucine from 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) and 1-aminocyclopentanecarboxylic acid: Fmoc-OSu (3.13 g, 9.3 mmol) was added to a mixture of acetonitrile/water (100 mL) and sodium bicarbonate (NaHCO3, 1.63 g, 1.4 mmol) containing 1-aminocyclopentanecarboxylic acid (1.0 g, 7.8 mmol) and sodium bicarbonate (NaHCO3, 1.63 g, 1.4 mmol). 19.4 mmol) in a mixed acetonitrile/water (100 mL, 1:1 v/v) solution. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, most of the solvent was removed by distillation under reduced pressure. Subsequently, the pH of the reaction mixture was adjusted to 2 with 2N hydrochloric acid (HCl) and extracted with dichloromethane (DCM). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and then concentrated. Finally, the residue was purified by silica gel fast column chromatography (petroleum ether/ethyl acetate=20:1) to afford the target product 1 -(((9H-fluoren-9-yl)methoxy)carbonylamino)cyclopentanecarboxylic acid (Compound 4 of Example A, 0.75 g, 28% yield) as a white solid.
References
[1] Journal of the American Chemical Society, 2000, vol. 122, # 37, p. 8898 - 8909
[2] Patent: WO2012/119941, 2012, A1. Location in patent: Page/Page column 110
[3] Journal of the American Chemical Society, 2003, vol. 125, # 23, p. 6852 - 6853
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 18, p. 5694 - 5706
Fmoc-cycloleucine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fmoc-cycloleucine manufacturers
- Product
- N-Fmoc-1-amino-1-cyclopentanecarboxylic acid 117322-30-2
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- Fmoc-cycloleucine 117322-30-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31