20-O-Demethyl-AP3

Product Name: 20-O-Demethyl-AP3
CAS No.: 72902-38-6
Chemical Name: 20-O-Demethyl-AP3
Synonyms: PDM3;ANSAMITOCIN DERIV;20-O-Demethyl-AP3;Mertansine Impurity 4;Ansamitocin derivative TN-006;Maytansine, 2'-de(acetylmethylamino)-O(20)-demethyl-2'-methyl;Maytansine, 2'-de(acetylmethylamino)-O(20)-demethyl-2'-methyl;Maytansine, 2'-de(acetylmethylamino)-O20-demethyl-2'-methyl- (9CI);(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-12,21-dihydroxy-20-methoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl 2-methylpropanoate
CBNumber: CB43297108
Molecular Formula: C31H41ClN2O9
Formula Weight: 621.12
MOL File: 72902-38-6.mol

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20-O-Demethyl-AP3 Property

Boiling point:: 845.8±65.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
pka: 8.08±0.70(Predicted)
InChIKey: YQVKSZNVVCIETH-NYSCBQEQNA-N

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Hazard and Precautionary Statements (GHS)

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20-O-Demethyl-AP3 Chemical Properties,Usage,Production

Description

20-O-Demethyl-AP3 is a secondary metabolite derived from Ansamitocin P-3, and Ansamitocin P-3 is a macrocyclic antitumor antibiotic exerting its therapeutic effects by inhibiting microtubules.

Uses

20-O-Demethyl-AP3 is a minor metabolite of Ansamitocin P-3. Ansamitocin P-3, a microtubule inhibitor, is a macrocyclic antitumor antibiotic[1].

References

[1] Zhongfa Liu, et al. Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry. J Mass Spectrom. 2005 Mar;40(3):389-99. DOI:10.1002/jms.800

20-O-Demethyl-AP3 Preparation Products And Raw materials

Raw materials

Preparation Products

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72902-38-6, 20-O-Demethyl-AP3Related Search:

ANSAMITOCIN DERIV

PDM3

Mertansine Impurity 4

20-O-Demethyl-AP3

Ansamitocin derivative TN-006

Maytansine, 2'-de(acetylmethylamino)-O20-demethyl-2'-methyl- (9CI)

Maytansine, 2'-de(acetylmethylamino)-O(20)-demethyl-2'-methyl

(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-12,21-dihydroxy-20-methoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl 2-methylpropanoate

Maytansine, 2'-de(acetylmethylamino)-O(20)-demethyl-2'-methyl

72902-38-6

C31H41ClN2O9