MAREIN

Product Name: MAREIN
CAS No.: 535-96-6
Chemical Name: MAREIN
Synonyms: MAREIN;MAREIN hplc;MAREIN WITH HPLC;OKANIN-4'-O-GLUCOSIDE;Marein, 10 mM in DMSO;Okaini 4’-O-β-D-glucopyranoside;Okaini 4'-O-β-D-glucopyranoside;2',3,3',4,4'-PENTAHYDROXY-4'-GLUCOSYLCHALCONE;(E)-4'-(β-D-Glucopyranosyloxy)-2',3,3',4-tetrahydroxychalcone;(E)-3-(3,4-dihydroxyphenyl)-1-[4-(?-D-glucopyranosyloxy)-2,3-dihydroxyphenyl]-2-propen-1-one
CBNumber: CB4330620
Molecular Formula: C21H22O11
Formula Weight: 450.39
MOL File: 535-96-6.mol

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MAREIN Property

Melting point:: 197-202°C
Boiling point:: 835.4±65.0 °C(Predicted)
Density: 1.664±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO: soluble
form: A crystalline solid
pka: 6.92±0.40(Predicted)
color: Light yellow to yellow
InChIKey: XGEYXJDOVMEJNG-UOWIVAOKNA-N
SMILES: [C@@H]1([C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)OC1C=CC(C(=O)/C=C/C2C=CC(O)=C(O)C=2)=C(O)C=1O |&1:0,1,3,4,6,r|
LogP: -0.180 (est)

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Safety

Hazard Codes: Xi

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FM65433
Product name: Marein
Packaging: 1mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM65433
Product name: Marein
Packaging: 2mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 8609CP
Product name: Marein
Packaging: 1mg
Price: $117
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FM65433
Product name: Marein
Packaging: 5mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0135183
Product name: Marein
Purity: 98.65%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

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MAREIN Chemical Properties,Usage,Production

Uses

Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3].

Definition

ChEBI: Marein is a member of flavonoids and a glycoside.

References

[1] B Orlikova, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. DOI:10.3892/or.2012.1870
[2] Baoping Jiang, et al. Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells. Phytomedicine. 2016 Aug 15;23(9):891-900. DOI:10.1016/j.phymed.2016.05.004
[3] Baoping Jiang, et al. Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells. Free Radic Res. 2016;50(11):1173-1187. DOI:10.1080/10715762.2016.1222374

MAREIN Preparation Products And Raw materials

Raw materials

Preparation Products

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MAREIN Suppliers

China 111 France 1 Germany 2 Japan 1 United Kingdom 7 United States 8 USA 1 Global 131

Chengdu Bioanseis Phytochemicals Co., Ltd.

Tel: 13518187787
Email: 632977132@qq.com
Country: China
ProdList: 281
Advantage: 58

Jiangsu Yongjian Pharmaceutical Technology Co., Ltd

Tel: 17701422015
Email: 3582572959@qq.com
Country: China
ProdList: 979
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

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View Lastest Price from MAREIN manufacturers

Career Henan Chemical Co

Product: Marein 535-96-6
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-25

535-96-6, MAREINRelated Search:

hydroxygenkwanin Quercetin-7-O-β-D-glucopyranoside Naringenin 7-O-β-D-Glucuronide (Mixture of Diastereomers) 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one OKANIN Taxifolin 7-O-β-D-glucoside MOSLOFLAVONE MEDICAGOL PONCIRIN MARITIMEIN nepitrin MAREIN Quercetagetin-7-O-glucoside centaurein 6-HYDROXYLUTEOLIN-7-BETA-D-GLUCOSE MAREIN(P) MAREIN(SH) MAREIN(SECONDARY STANDARD)

(E)-4'-(β-D-Glucopyranosyloxy)-2',3,3',4-tetrahydroxychalcone

(E)-3-(3,4-dihydroxyphenyl)-1-[4-(beta-D-glucopyranosyloxy)-2,3-dihydroxyphenyl]-2-propen-1-one

MAREIN WITH HPLC

MAREIN hplc

2',3,3',4,4'-PENTAHYDROXY-4'-GLUCOSYLCHALCONE

MAREIN

OKANIN-4'-O-GLUCOSIDE

Okaini 4’-O-β-D-glucopyranoside

2-Propen-1-one, 3-(3,4-dihydroxyphenyl)-1-[4-(β-D-glucopyranosyloxy)-2,3-dihydroxyphenyl]-, (2E)-

(E)-3-(3,4-dihydroxyphenyl)-1-[4-(?-D-glucopyranosyloxy)-2,3-dihydroxyphenyl]-2-propen-1-one

GLUT1,HDAC,Inhibitor,Akt,inhibit,antioxidative,Marein,Histone deacetylases,antihypertensive,AMP-activated protein kinase,IRS,glycoside,antihyperlipidemic,AMPK,antidiabetic,GSK-3β,FoxO1,neuroprotective,CaMKK

(E)-1-(2,3-Dihydroxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one

Marein, 10 mM in DMSO

Okaini 4'-O-β-D-glucopyranoside

535-96-6

C21H22O11

reagent

Chalcones