Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester

Product Name: Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester
CAS No.: 2228857-34-7
Chemical Name: Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester
Synonyms: DBCO-PEG1-NHS Ester;DBCO-NH-PEG1-CH2CH2COONHS;DBCO-NH-PEG1-CH2CH2COONHS ester;Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester;2,5-Dioxo-1-pyrrolidinyl 3-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethoxy]propanoate
CBNumber: CB43309391
Molecular Formula: C28H27N3O7
Formula Weight: 517.54
MOL File: 2228857-34-7.mol

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Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester Property

Density: 1.39±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
form: Solid
pka: 15.12±0.46(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-24018
Product name: DBCO-PEG1-NHSester
Purity: 98%
Packaging: 50mg
Price: $430
Updated: 2021/12/16

BroadPharm

Product number: BP-24018
Product name: DBCO-PEG1-NHSester
Purity: 98%
Packaging: 100mg
Price: $680
Updated: 2021/12/16

BroadPharm

Product number: BP-24018
Product name: DBCO-PEG1-NHSester
Purity: 98%
Packaging: 250mg
Price: $1340
Updated: 2021/12/16

purepeg

Product number: 488401
Product name: DBCO-NH-PEG1-CH2CH2COONHSester
Purity: min.95%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester Chemical Properties,Usage,Production

Description

DBCO-PEG1-NHS Ester is a PEG containing molecule containing an NHS ester moiety that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG1-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester Suppliers

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2228857-34-7, Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl esterRelated Search:

DBCO-PEG1-amine 5,8,11,14,17,20-Hexaoxa-2,23-diazaheptacosanoic acid, 27-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-24,27-dioxo-, 1,1-dimethylethyl ester DBCO-PEG3-CH2CO-NHS DBCO-PEG4-amine DBCO-PEG4-SE DBCO-NHS Ester DBCO-PEG2-NH-Boc DBCO-PEG4-DBCO DBCO-(CH2)2-NH2-CO-(CH2)3COOH-NHS DBCO-PEG3-acid Azadibenzocyclooctyne-Biotin conjugate 4,7,10,13-Tetraoxa-16-azaheneicosanoic acid, 21-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 2,3,5,6-tetrafluorophenyl ester DBCO-NH-(CH2)4COOH DBCO-PEG3-amine DBCO-NH-Boc

Azadibenzocyclooctyne-PEG1-N-hydroxysuccinimidyl ester

DBCO-NH-PEG1-CH2CH2COONHS ester

DBCO-PEG1-NHS Ester

DBCO-NH-PEG1-CH2CH2COONHS

2,5-Dioxo-1-pyrrolidinyl 3-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethoxy]propanoate

2228857-34-7