ChemicalBook > CAS DataBase List > 1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE

Product Name
1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE
CAS No.
94284-66-9
Chemical Name
1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE
Synonyms
2-methylamino-4-methyl-5-acetylthiazole;1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE;1-[4-Methyl-2-(methylamino)-5-thiazolyl]ethanone;Ethanone, 1-[4-methyl-2-(methylamino)-5-thiazolyl]-;1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one
CBNumber
CB4332826
Molecular Formula
C7H10N2OS
Formula Weight
170.23
MOL File
94284-66-9.mol
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1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Property

Melting point:
201-203 °C
Boiling point:
281.9±32.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
4.01±0.10(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0059746
Product name
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one
Packaging
100mg
Price
$71
Updated
2021/12/16
Ark Pharm
Product number
P000199330
Product name
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone
Purity
97%
Packaging
100mg
Price
$81
Updated
2021/12/16
ChemScene
Product number
CS-0059746
Product name
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one
Packaging
250mg
Price
$107
Updated
2021/12/16
Ark Pharm
Product number
P000199330
Product name
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethanone
Purity
97%
Packaging
250mg
Price
$121
Updated
2021/12/16
ChemScene
Product number
CS-0059746
Product name
1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one
Packaging
1g
Price
$266
Updated
2021/12/16
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1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Chemical Properties,Usage,Production

Synthesis

598-52-7

1694-29-7

94284-66-9

General procedure for the synthesis of 1-(4-methyl-2-(methylamino)thiazol-5-yl)ethanone from N-methylthiourea and 3-chloro-2,4-pentanedione: 1-methylthiourea (6.00 g, 66.6 mmol) was dissolved in a mixture of methanol (130 mL) and pyridine (5 mL) and cooled in an ice bath. Subsequently, 3-chloropentane-2,4-dione (8.96 mL, 66.6 mmol) was added slowly and dropwise to this cooled solution. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the resulting white solid precipitate was collected by filtration and washed with ether (20 mL) to give the final target product 1-(4-methyl-2-(methylamino)thiazol-5-yl)ethanone (8.94 g, 79% yield). The product was characterized by 1H-NMR (DMSO-d6): δ 2.39 (s, 3H, CH3), 2.49 (s, 3H, CH3), 2.91 (s, 3H, CH3), 9.12 (s, 1H, NH). Mass spectrometry (ESI) analysis showed a calculated value of 171.06 (C7H11N2OS+) for m/z [M+H]+ and a measured value of 171.06.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 139, p. 762 - 772
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1662 - 1675
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 11, p. 4367 - 4378
[4] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 10, p. 3135 - 3140
[5] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 24, p. 7349 - 7356

1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE Suppliers

China 25 India 1 United States 3 Global 29
Shanghai JiYi Biotechnology Co. Ltd.
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Amadis Chemical Company Limited
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Aikon International Limited
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025-66061636 18013972705
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Yujinpharma(Tianjin) Technology Co.,Ltd.
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Labnetwork lnc.
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Henan Lien Chemical Products Co., Ltd.
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Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd
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94284-66-9, 1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONERelated Search:

N-(5,5-DIMETHYL-7-OXO-4,5,6-TRIHYDROBENZOTHIAZOL-2-YL)ETHANAMIDE 1-(3-((2-CHLOROPHENYL)AMINO)-5-METHYL-2,4-THIAZOLYL)ETHAN-1-ONE 1-(4-METHYL-2-PHENYLAMINO-THIAZOL-5-YL)-ETHANONE 1-(4-METHYL-2-MORPHOLINO-1,3-THIAZOL-5-YL)-3-(2-THIENYL)PROP-2-EN-1-ONE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-2-(4-CHLOROPHENYLTHIO)PROPANAMIDE (2-CHLORO(3-PYRIDYL))-N-(5-METHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))FORMAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(3-(TRIFLUOROMETHYL)PHENYL)FORMAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-4-METHYLPENT-2-ENAMIDE N-(5-METHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(4-METHYLPHENYL)FORMAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(4-METHOXYPHENYL)FORMAMIDE N-(5-METHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(2-PHENOXY(3-PYRIDYL))FORMAMIDE N-(5-METHYL-7-OXO-4,5,6-TRIHYDROBENZOTHIAZOL-2-YL)ETHANAMIDE 2-(4-CHLOROPHENYLTHIO)-N-(7-OXO-5-PHENYL(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))PROPANAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-3-PYRIDYLFORMAMIDE N-(5-(2-METHYLPROPYL)-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))-2-THIENYLFORMAMIDE 2-(2,4-DICHLOROPHENOXY)-N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))ETHANAMIDE N-(5,5-DIMETHYL-7-OXO(4,5,6-TRIHYDROBENZOTHIAZOL-2-YL))(2-CHLORO(3-PYRIDYL))FORMAMIDE N-(3-ACETYL-4-METHYL(2,5-THIAZOLYL))-2,2,2-TRIFLUOROETHANAMIDE

  • 1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE
  • 2-methylamino-4-methyl-5-acetylthiazole
  • 1-(4-Methyl-2-(methylamino)thiazol-5-yl)ethan-1-one
  • Ethanone, 1-[4-methyl-2-(methylamino)-5-thiazolyl]-
  • 1-[4-Methyl-2-(methylamino)-5-thiazolyl]ethanone
  • 94284-66-9