ITX-5061 HCl
- Product Name
- ITX-5061 HCl
- CAS No.
- 1252679-52-9
- Chemical Name
- ITX-5061 HCl
- Synonyms
- ITX-5061;ITX506 HCl;ITX-5061 HCl;ITX-5061 hydrochloride;ITX-5061 hydrochloride (ITX5061);N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride;N-(5-(tert-Butyl)-2-methoxy-3-(methylsulfonamido)phenyl)-2-(4-(2-morpholinoethoxy)naphthalen-1-yl)-2-oxoacetamide hydrochloride , ITX5061
- CBNumber
- CB43333732
- Molecular Formula
- C30H38ClN3O7S
- Formula Weight
- 620.16
- MOL File
- 1252679-52-9.mol
ITX-5061 HCl Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 83.3 mg/mL (134.32 mM)
- form
- Solid
- color
- Light yellow to light brown
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0016951
- Product name
- ITX5061
- Packaging
- 5mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- CS-0016951
- Product name
- ITX5061
- Packaging
- 10mg
- Price
- $980
- Updated
- 2021/12/16
- Product number
- CS-0016951
- Product name
- ITX5061
- Packaging
- 50mg
- Price
- $3000
- Updated
- 2021/12/16
ITX-5061 HCl Chemical Properties,Usage,Production
Uses
ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).
in vivo
ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1). Treatment of ITX5061 (30 mg/kg/day) for mice results in a 50% increase in HDL-C levels compare to baseline. ApoA-I levels are moderately (+15 %) but significantly increased in ITX5061-treated HuAITg mice, compare to mice receive vehicle. ITX5061 significantly decreases HDL-CE catabolism with an FCR of 1.86±0.40 pools/d vs 2.47±0.26 pools/d in the control group (P<0.05), while calculated production rates are identical in both groups (129±24 μg/g/d vs 129±16 μg/g/d). Moreover, accumulation of [3H] CE in the liver is significantly lower in ITX5061-treated mice indicating that increased HDL-CE levels are due to reduced uptake by the liver[1].
References
[1] Masson D, et al. Increased HDL cholesterol and apoA-I in humans and mice treated with a novel SR-BI inhibitor. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2054-60. DOI:10.1161/ATVBAHA.109.191320
ITX-5061 HCl Preparation Products And Raw materials
Raw materials
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