SP187
- Product Name
- SP187
- CAS No.
- 615253-61-7
- Chemical Name
- SP187
- Synonyms
- UV4);UV-4B;SP187;MON-?DNJ;SP-187,SP187;SP187 (MON-?DNJ;SP187, 10 mM in DMSO;3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-(9-methoxynonyl)-, (2R,3R,4R,5S)-
- CBNumber
- CB43339714
- Molecular Formula
- C16H33NO5
- Formula Weight
- 319.44
- MOL File
- 615253-61-7.mol
SP187 Property
- Boiling point:
- 475.0±40.0 °C(Predicted)
- Density
- 1.128±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 13.72±0.70(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-7214
- Product name
- SP187
- Purity
- 99.30%
- Packaging
- 1mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- CS-7214
- Product name
- SP187
- Purity
- 99.30%
- Packaging
- 5mg
- Price
- $720
- Updated
- 2021/12/16
- Product number
- CS-7214
- Product name
- SP187
- Purity
- 99.30%
- Packaging
- 10mg
- Price
- $1224
- Updated
- 2021/12/16
- Product number
- CS-7214
- Product name
- SP187
- Purity
- 99.30%
- Packaging
- 20mg
- Price
- $2160
- Updated
- 2021/12/16
SP187 Chemical Properties,Usage,Production
Uses
SP187 is a host-targeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.
in vivo
The efficacy of SP187 (UV-4), the active free base component of UV-4B, and UV-5, the most potent iminosugar tested in vitro, is first assessed using a mouse model of EBOV infection. In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12 hour intervals for UV-5 or TID at approximately 8 hour intervals for SP187. The selected doses and schedule are based on tolerability studies in na?ve mice. No efficacy is observed in the iminosugar treated mice as compared to the vehicle control[1].
References
[1] Warfield KL, et al. Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo. Antiviral Res. 2017 Feb;138:22-31. DOI:10.1016/j.antiviral.2016.11.019
SP187 Preparation Products And Raw materials
Raw materials
Preparation Products
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