1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide

Product Name: 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
CAS No.: 1917294-46-2
Chemical Name: 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
Synonyms: PF4745637;PF-4745637;PF 4745637;PF-04745637;PF-04746537;PF-04745637, 10 mM in DMSO;1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide;1-(4-Chlorophenyl)- N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]cyclopentanecarboxamide;1-(4-Chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentane-1-carboxamide;Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]-
CBNumber: CB43340668
Molecular Formula: C27H32ClF3N2O2
Formula Weight: 509.0033896
MOL File: 1917294-46-2.mol

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1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Property

Boiling point:: 651.8±55.0 °C(Predicted)
Density: 1.281±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 12.14±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Chemical Properties,Usage,Production

Uses

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].

Biological Activity

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1]. Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].

in vivo

Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin^[1].

IC 50

TRPA1: 17 nM (IC₅₀)

References

[1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.

1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Suppliers

China 29 United States 1 Global 30

Bide Pharmatech Ltd.

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Changzhou Chenhong Biotechnology Co., Ltd.

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1917294-46-2, 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamideRelated Search:

1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide

PF-04745637

1-(4-Chlorophenyl)- N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]cyclopentanecarboxamide

PF 4745637

PF4745637

PF-4745637

PF-04746537

PF04745637,Inhibitor,bowel,TRPA1,disease,inhibit,respiratory,PF-04745637,Transient receptor potential channels,inflammatory,TRP Channel,skin

Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]-

PF-04745637, 10 mM in DMSO

1-(4-Chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentane-1-carboxamide

1917294-46-2

C27H32ClF3N2O2