ChemicalBook > CAS DataBase List > TUG-905
TUG-905
- Product Name
- TUG-905
- CAS No.
- 1390641-90-3
- Chemical Name
- TUG-905
- Synonyms
- TUG-905;TUG905,TUG 905;Benzenepropanoic acid, 2-fluoro-4-[[[2'-methyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methyl]amino]-
- CBNumber
- CB43344772
- Molecular Formula
- C27H30FNO5S
- Formula Weight
- 499.59
- MOL File
- 1390641-90-3.mol
More
Less
TUG-905 Property
- Boiling point:
- 718.2±60.0 °C(Predicted)
- Density
- 1.268±0.06 g/cm3(Predicted)
- pka
- 4.76±0.10(Predicted)
More
Less
TUG-905 Chemical Properties,Usage,Production
Uses
TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].
in vivo
TUG-905 (2.0 μL, 1.0 mM; i.c.v.; twice a day for 6 days) reduces body mass and exhibited a trend toward reducing caloric intake[1].
| Animal Model: | 6 weeks, Male Swiss mice[1] |
| Dosage: | 2.0 μL, 1.0 mM |
| Administration: | I.c.v.; twice a day for 6 days |
| Result: | Reduced body mass and exhibited a trend toward reducing caloric intake, and induced an increase of IL10 and IL6 in the hypothalamus, and increased the POMC mRNA expression. |
References
[1] Dragano NRV, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017 Apr 26;14(1):91. DOI:10.1186/s12974-017-0869-7
[2] Engel DF, et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci Rep. 2020 Jul 6;10(1):11047. DOI:10.1038/s41598-020-68110-2
TUG-905 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
TUG-905 Suppliers
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 29257
- Advantage
- 58
- Tel
- +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19961
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58