hVEGF-IN-1

Product Name: hVEGF-IN-1
CAS No.: 1637443-98-1
Chemical Name: hVEGF-IN-1
Synonyms: hVEGF-IN-1;hVEGF-IN-1, >98%;hVEGF inhibitor 1;hVEGF-IN-1, 10 mM in DMSO;1-Piperazinepropanamide, N-[2-[4-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-2-quinazolinyl]phenyl]-4-methyl-;N-(2-(4-((4-(2-(Diethylamino)ethoxy)phenyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide;Inhibitor,quinazoline,IRES-A,migration,hVEGF IN 1,hVEGFIN1,tumor,G-rich,inhibit,VEGFR,Vascular endothelial growth factor receptor,VEGF-A
CBNumber: CB43350595
Molecular Formula: C34H43N7O2
Formula Weight: 581.75
MOL File: 1637443-98-1.mol

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hVEGF-IN-1 Property

Boiling point:: 710.9±60.0 °C(Predicted)
Density: 1.188±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (42.97 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: 14.43±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7769
Product name: hVEGF-IN-1
Purity: 98.31%
Packaging: 1mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-7769
Product name: hVEGF-IN-1
Purity: 98.31%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-7769
Product name: hVEGF-IN-1
Purity: 98.31%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

DC Chemicals

Product number: DC10580
Product name: hVEGF-IN-1
Purity: >98%
Packaging: 100mg
Price: $1100
Updated: 2021/12/16

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hVEGF-IN-1 Chemical Properties,Usage,Production

Uses

hVEGF-IN-1, a quinazoline derivative, could specifically bind to the G-rich sequence in the internal ribosome entry site A (IRES-A) and destabilize the G-quadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM in SPR experiments. hVEGF-IN-1 could hinder tumor cells migration and repress tumor growth by decreasing VEGF-A protein expression[1].

in vivo

hVEGF-IN-1 (compound 1) (7.5 mg/kg; i.p. once daily for 20 d) inhibits tumor growth in a human breast tumor xenograft^[1].

Animal Model:	BALB/c female nude mice were implanted MCF-7 cells^[1]
Dosage:	7.5 mg/kg
Administration:	I.p. once daily for 20 days
Result:	Reduced the tumor volume to <300 mm³. Reduced the tumor weight around 60.1% to a final weight of 0.18 g. Decreased the VEGF-A level in tumor tissue.

References

[1] Wang SK, et, al. Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents. J Med Chem. 2017 Jul 13;60(13):5306-5319. DOI:10.1021/acs.jmedchem.6b01444

hVEGF-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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hVEGF-IN-1 Suppliers

China 46 United States 6 Global 52

MedChemexpress LLC

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Shanghai JiYi Biotechnology Co. Ltd.

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Angel Pharmatech, Ltd.

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TargetMol Chemicals Inc.

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InvivoChem

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1637443-98-1, hVEGF-IN-1Related Search:

hVEGF-IN-1

hVEGF inhibitor 1

hVEGF-IN-1, >98%

1-Piperazinepropanamide, N-[2-[4-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-2-quinazolinyl]phenyl]-4-methyl-

Inhibitor,quinazoline,IRES-A,migration,hVEGF IN 1,hVEGFIN1,tumor,G-rich,inhibit,VEGFR,Vascular endothelial growth factor receptor,VEGF-A

N-(2-(4-((4-(2-(Diethylamino)ethoxy)phenyl)amino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

hVEGF-IN-1, 10 mM in DMSO

1637443-98-1

C34H43N7O2