ChemicalBook > CAS DataBase List > Eravacycline (dihydrochloride)

Eravacycline (dihydrochloride)

Product Name: Eravacycline (dihydrochloride)
CAS No.: 1334714-66-7
Chemical Name: Eravacycline (dihydrochloride)
Synonyms: TP-434-046;Eravacyline;TP-434 2HCl;Eravacycline HCl;ERAVACYCLINE 2HCL;Epicycline hydrochloride;Elacycline Hydrochloride;Olutasidenib Impurity 16;Eravacycline (dihydrochloride);Eravacycline dihydrochloride, ≥96%
CBNumber: CB43356153
Molecular Formula: C27H32ClFN4O8
Formula Weight: 595.02
MOL File: 1334714-66-7.mol

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Eravacycline (dihydrochloride) Property

storage temp.: -80°C, protect from light, stored under nitrogen,unstable in solution, ready to use.
form: Solid
color: Light yellow to yellow
Water Solubility: Water : 50 mg/mL (79.18 mM)
InChIKey: XCNSMXGRPDKXPD-WWKMUIPSNA-N
SMILES: O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=C(NC(=O)CN4CCCC4)C(O)=C3C(=O)C1=C2O)F)=O.Cl |&1:1,9,13,16,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7480
Product name: Eravacyclinedihydrochloride
Purity: 98.01%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-7480
Product name: Eravacyclinedihydrochloride
Purity: 98.01%
Packaging: 10mg
Price: $84
Updated: 2021/12/16

AK Scientific

Product number: 1913DN
Product name: Eravacyclinedihydrochloride
Packaging: 25mg
Price: $590
Updated: 2021/12/16

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Eravacycline (dihydrochloride) Chemical Properties,Usage,Production

Uses

Eravacycline dihydrochloride (TP-434 dihydrochloride) is a potent and broad-spectrum antibacterial agent.

in vivo

Eravacycline dihydrochloride is active in multiple murine models of infection against clinically important Gram-positive and Gram-negative pathogens. Eravacycline is efficacious in mouse septicemia models, demonstrating 50% protective dose values of ≤1 mg/kg of body weight once a day (q.d.) against Staphylococcus aureus. The PD₅₀ values against Escherichia coli isolates are 1.2 to 4.4 mg/kg q.d^[5].

References

[1] Seifert H, et al. In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii. Int J Antimicrob Agents. 2017 Jul 10. DOI:10.1016/j.ijantimicag.2017.06.022
[2] Zhao M, et al. In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model. Antimicrob Agents Chemother. 2017 Jun 27;61(7). DOI:10.1128/AAC.00250-17
[3] Xiao XY, et al. Fluorocyclines: a potent, broad spectrum antibacterial agent. J Med Chem. 2012 Jan 26;55(2):597-605. DOI:10.1021/jm201465w
[4] Sutcliffe JA, et al. Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens. Antimicrob Agents Chemother. 2013 Nov;57(11):5548-58. DOI:10.1128/AAC.01288-13
[5] Grossman TH, et al. Eravacycline (TP-434) is efficacious in animal models of infection. Antimicrob Agents Chemother. 2015 May;59(5):2567-71. DOI:10.1128/AAC.04354-14

Eravacycline (dihydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Eravacycline (dihydrochloride) manufacturers

Moxin Chemicals

Product: Eravacycline Dihydrochloride 1334714-66-7
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 100000
Release date: 2025-03-24

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Eravacycline Dihydrochloride 1334714-66-7
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2025-03-21

Zhuozhou Wenxi import and Export Co., Ltd

Product: Eravacycline dihydrochloride 1334714-66-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

1334714-66-7, Eravacycline (dihydrochloride)Related Search:

Eravacycline (dihydrochloride)

Eravacyline

TP-434-046

ERAVACYCLINE 2HCL

TP-434 2HCl

Eravacycline HCl

Eravacycline diHClide (TP-434 diHClide)

(4S,4aS,5aR,12aS)-4-(Dimethylamino)-7-fluoro-3,10,12,12a-tetrahydroxy-1,11-dioxo-9-(2-(pyrrolidin-1-yl)acetamido)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide dihydrochloride

Olutasidenib Impurity 16

Elacycline Hydrochloride

Epicycline hydrochloride

Eravacycline dihydrochloride (TP-434 dihydrochloride)

Eravacycline dihydrochloride, ≥96%

1334714-66-7

C27H33Cl2FN4O8