Ethosuximide D5
- Product Name
- Ethosuximide D5
- CAS No.
- 1989660-59-4
- Chemical Name
- Ethosuximide D5
- Synonyms
- Ethosuximide D5;Ethoxzolamide-d5;3-(ethyl-1,1,2,2,2-d5)-3-methyl-2,5-pyrrolidinedione
- CBNumber
- CB43356229
- Molecular Formula
- C7H11NO2
- Formula Weight
- 141.17
- MOL File
- 1989660-59-4.mol
Ethosuximide D5 Property
- storage temp.
- Store at -20°C
- solubility
- Methanol: soluble
- form
- A solid
Ethosuximide D5 Chemical Properties,Usage,Production
Biological Activity
Ethosuximide-d5 is intended for use as an internal standard for the quantification of ethosuximide by GC- or LC-MS. Ethosuximide is an anticonvulsant.1,2,3,4,5 It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg.1 Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions.2 It also inhibits tonic hindlimb extension induced by pentylenetetrazole or brainstem stimulation (ED50s = 35 and 70 mg/kg, respectively), as well as leptazol-induced clonic seizures (ED50 = 230 mg/kg), in rats.3,4 Ethosuximide reduces resting tremor by 60% in a macaque model of Parkinson's disease induced by MPTP when administered at a dose of 150 mg/animal for 5 days.5 Formulations containing ethosuximide have been used in the treatment of petit mal seizures.
References
1.Nahorski, S.R.Biochemical effects of the anticonvulsants trimethadione, ethosuximide and chlordiazepoxide in rat brainJ. Neurochem.19(8)1937-1946(1972) 2.Norton, P.R.The effects of drugs on barbiturate withdrawal convulsions in the ratJ. Pharm. Pharmacol.22(10)763-766(1970) 3.Consroe, P.F., and Wolkin, A.L.Anticonvulsant interaction of cannabidiol and ethosuximide in ratsJ. Pharm. Pharmacol.29(8)500-501(1977) 4.Chiu, P., and Burnham, W.M.The effect of anticonvulsant drugs on convulsions triggered by direct stimulation of the brainstemNeuropharmacology21(4)355-359(1982) 5.Gomez-Mancilla, B., Latulippe, J.F., Boucher, R., et al.Effect of ethosuximide on rest tremor in the MPTP monkey modelMov. Disord.7(2)137-141(1992)
Ethosuximide D5 Preparation Products And Raw materials
Raw materials
Preparation Products
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