CY-09
- Product Name
- CY-09
- CAS No.
- 1073612-91-5
- Chemical Name
- CY-09
- Synonyms
- CY-09;CS-2756;CY 09;CY09;CY09;CY 09;CY-09;CY-09, 10 mM in DMSO;CY-09,Inhibitor,NOD-like Receptor (NLR),inhibit,CY09;4-[[4-Oxo-2-thioxo-3-[3-(trifluoromethyl)benzyl]thiazolidin-5-ylidene]methyl]benzoic Acid;(E)-4-((4-oxo-2-thioxo-3-(3-(trifluoromethyl)benzyl)thiazolidin-5-ylidene)methyl)benzoic acid;4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid;Benzoic acid, 4-[[4-oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]-
- CBNumber
- CB43357761
- Molecular Formula
- C19H12F3NO3S2
- Formula Weight
- 423.43
- MOL File
- 1073612-91-5.mol
CY-09 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:65.0(Max Conc. mg/mL);152.61(Max Conc. mM)
- form
- A crystalline solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 6436
- Product name
- CY09
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $186
- Updated
- 2021/12/16
- Product number
- 6436
- Product name
- CY09
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $771
- Updated
- 2021/12/16
- Product number
- C998365
- Product name
- CY-09
- Packaging
- 5mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- C998365
- Product name
- CY-09
- Packaging
- 50mg
- Price
- $1020
- Updated
- 2021/12/16
- Product number
- CS-8057
- Product name
- CY-09
- Purity
- >98.0%
- Packaging
- 1mg
- Price
- $60
- Updated
- 2021/12/16
CY-09 Chemical Properties,Usage,Production
Uses
CY-09, exhibits a dose-dependent inhibitory effect on monosodium urate (MSU), nigericin, ATP-induced caspase-1 activation and IL-1β secretion at the doses of 1 to10 μM in LPS-primed bone marrow-derived macrophages (BMDMs). CY-09 is an NLRP3 inhibitor.
Biological Activity
CY-09 is an NLRP3 inflammasone inhibitor. CY-09 binds directly to the ATP-binding motif of NLRP3 NACHT domain and inhibits its ATPase activity, blocking NLRP3 inflammasome assembly and activation. In mouse models CY-09 showed therapeutic effects in type 2 diabetes and cryopyrin-associated auto-inflammatory syndrome (CAPS), which is caused by gain-of-function mutations of NLRP3.
in vivo
CY-09 treatment in vivo efficiently suppresses monosodium urate (MSU) injection-induced IL-1β production and neutrophil influx, suggesting that CY-09 can block MSU-induced NLRP3 inflammasome activation in vivo. CY-09 treatment also increases the survival of NLRP3 mutant mice up to days 30 to 48 even after treatment is stopped at day 25. The caspase-1 cleavage observed in adipose tissue of high-fat diet (HFD)-treated mice is also suppressed by CY-09[1].
IC 50
NLRP3
storage
Store at +4°C
CY-09 Preparation Products And Raw materials
Raw materials
Preparation Products
CY-09 Suppliers
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- 021-50795510 4000665055
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