Simmitecan Hydrochloride

Product Name: Simmitecan Hydrochloride
CAS No.: 1247847-78-4
Chemical Name: Simmitecan Hydrochloride
Synonyms: Simmitecan Hydrochloride
CBNumber: CB43358869
Molecular Formula: C34H39ClN4O6
Formula Weight: 635.14966
MOL File: 1247847-78-4.mol

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

Simmitecan Hydrochloride Chemical Properties,Usage,Production

Uses

Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2].

in vivo

Simmitecan hydrochloride (3.75, 7.5 and 15 mg/kg, i.v. bolus) shows mean elimination half-life t_1/2 of approximately 1.4 h in SD rats^[2].

References

[1] Rini B, et al. A phase I/II study of lenalidomide in combination with sunitinib in patients with advanced or metastatic renal cell carcinoma. Ann Oncol. 2014 Sep;25(9):1794-1799. DOI:10.1093/annonc/mdu212
[2] Hu ZY, et al. Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals. Acta Pharmacol Sin. 2013 Nov;34(11):1437-48. DOI:10.1038/aps.2013.74

Simmitecan Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Simmitecan Hydrochloride Suppliers

China 7 United States 1 Global 8

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Shochem(Shanghai)Co.,Ltd

Tel: +86-021-51783479 +86-13816874662
Fax: 021-50800795
Email: info@shochem.com
Country: China
ProdList: 307
Advantage: 58

Shochem(Shanghai) Co.,Ltd

Tel: 86-21-50800795
Email: info@shochem.com
Country: CHINA
ProdList: 288
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29257
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

1247847-78-4, Simmitecan HydrochlorideRelated Search:

Simmitecan Hydrochloride

1247847-78-4