Ganglioside GM3
- Product Name
- Ganglioside GM3
- CAS No.
- 124579-05-1
- Chemical Name
- Ganglioside GM3
- Synonyms
- Neu5Aca2,3Galb1,4Glc Ceramide;Neu5Acα2, 3Galβ1, 4Glc Ceramide;Neu5Aca2,3Galb1,4Glc Ceramide Synonym:GM3;Neu5Acα2,?3Galβ1,?4Glc?Ceramide/Neu5Acα2,3Galβ1,4Glc Ceramide/Ganglioside GM3;Octadecanamide, N-[(1S,2R,3E)-1-[[[O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]-;(2S,4S,5R,6R)-5-Acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3S,4R,5R,6R)-4,5-dihydroxy-6-(((2S,3R,E)-3-hydroxy-2-stearamidooctadec-4-en-1-yl)oxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)-4-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid
- CBNumber
- CB43360811
- Molecular Formula
- C59H108N2O21
- Formula Weight
- 1181.51
- MOL File
- 124579-05-1.mol
Ganglioside GM3 Property
- Boiling point:
- 1260.2±65.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- form
- Solid
- pka
- 1.92±0.70(Predicted)
- color
- White to off-white
- InChIKey
- UIKPUUZBQYTDRX-WMWRIFHGNA-N
Ganglioside GM3 Chemical Properties,Usage,Production
Uses
Ganglioside GM3-d7 is deuterium labeled Ganglioside GM3. Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia[1][1][2][3].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Nihei W, et al. NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains. J Lipid Res. 2018 Nov;59(11):2181-2187. DOI:10.1194/jlr.M089201
[3] Inokuchi JI, et al. Pathophysiological Significance of GM3 Ganglioside Molecular Species With a Particular Attention to the Metabolic Syndrome Focusing on Toll-Like Receptor 4 Binding. Front Mol Biosci. 2022 May 30;9:918346. DOI:10.3389/fmolb.2022.918346
Ganglioside GM3 Preparation Products And Raw materials
Raw materials
Preparation Products
Ganglioside GM3 Suppliers
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View Lastest Price from Ganglioside GM3 manufacturers
- Product
- Neu5Aca2,3Galb1,4Glc Ceramide Synonym:?GM3 124579-05-1.
- Price
- US $0.00/mg
- Min. Order
- 25mg
- Purity
- 97%HPLC
- Supply Ability
- MG-KG
- Release date
- 2020-03-17