SUVN-D4010

Product Name: SUVN-D4010
CAS No.: 1428862-32-1
Chemical Name: SUVN-D4010
Synonyms: SUVN-D4010;SUVN-1004028;SUVN-D1003019;SUVN-D-1208045;Usmarapride free base;SUVN-D4010/ Usmarapride;1H-Indazole, 3-[5-[1-(3-methoxypropyl)-4-piperidinyl]-1,3,4-oxadiazol-2-yl]-1-(1-methylethyl)-
CBNumber: CB43361070
Molecular Formula: C21H29N5O2
Formula Weight: 383.49
MOL File: 1428862-32-1.mol

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SUVN-D4010 Property

Boiling point:: 541.9±60.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 7.84±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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SUVN-D4010 Chemical Properties,Usage,Production

Uses

Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1].

in vivo

Usmarapride (SUVN-D4010) (1-3 mg/kg; p.o.; Male Wistar rats 10-12 weeks old) free base attenuates the long-term memory deficits in object recognition test (ORT)^[1].
Usmarapride (1, 3, and 10 mg/kg; p.o.) free base significantly reverses the scopolamine-induced amnesia^[1].
Usmarapride free base shows a statistically significant effect at 3.0 mg/kg on both exploration time and recognition index^[1].
Usmarapride (SUVN-D4010) free base shows good oral exposures, good bioavailability, and good brain exposures in rats^[1].

IC 50

5-HT₄ Receptor: 44 nM (EC₅₀)

References

[1] Nirogi R, et al. Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease. J Med Chem. 2021;64(15):10641-10665. DOI:10.1021/acs.jmedchem.1c00703

SUVN-D4010 Preparation Products And Raw materials

Raw materials

Preparation Products

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SUVN-D4010 Suppliers

China 4 United States 2 Global 6

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-025-66113011 18626450290
Email: cb5@aikonchem.com
Country: China
ProdList: 10358
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5002
Advantage: 58

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29423
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

1428862-32-1, SUVN-D4010Related Search:

SUVN-D4010

SUVN-1004028

SUVN-D1003019

SUVN-D-1208045

Usmarapride free base

SUVN-D4010/ Usmarapride

1H-Indazole, 3-[5-[1-(3-methoxypropyl)-4-piperidinyl]-1,3,4-oxadiazol-2-yl]-1-(1-methylethyl)-

1428862-32-1