Fluxametamide

Product Name: Fluxametamide
CAS No.: 928783-29-3
Chemical Name: Fluxametamide
Synonyms: FLUXAMETAMIDE;Fluxametamide-002;Fluxametamide(mixture of isomers);inhibit,Inhibitor,γ-Aminobutyric acid Receptor,GABA Receptor,Fluxametamide,Gamma-aminobutyric acid Receptor;4-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((methoxyamino)methylene)-2-methylbenzamide;4-[5-(3,5-Dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[(methoxyamino)methylene]-2-methylbenzamide;Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[(methoxyamino)methylene]-2-methyl-
CBNumber: CB43364536
Molecular Formula: C20H16Cl2F3N3O3
Formula Weight: 474.26
MOL File: 928783-29-3.mol

More

Less

Fluxametamide Property

Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (263.57 mM);Water : < 0.1 mg/mL (insoluble)
pka: 11.29±0.46(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0029830
Product name: Fluxametamide
Purity: 99.74%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0029830
Product name: Fluxametamide
Purity: 99.74%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0029830
Product name: Fluxametamide
Purity: 99.74%
Packaging: 50mg
Price: $650
Updated: 2021/12/16

More

Less

Fluxametamide Chemical Properties,Usage,Production

Description

Fluxametamide is a novel isoxazoline insecticide that acts via distinctive antagonism of insect ligand-gated chloride channels, acts as an antagonist of GABA- and glutamate-gated chloride channels(IC50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls).

Uses

Fluxametamide is a novel insecticide belongs to a class of compounds called isoxazolines, which are potent inhibitors of γ-aminobutyric acid (GABA)-, glutamate-, and glycine-gated chloride channels in insects. However, this pesticidal mode of action (MOA) does not seem to be operative in mammals as neurotoxicity was not found in either the acute or subchronic neurotoxicity studies at the limit dose.

Definition

ChEBI: 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-[(methoxyamino)methylidene]-2-methylbenzamide is a benzamide obtained by formal condensation of the carboxy group of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid with the amino group of N-methoxymethanimidamide. It is a member of benzamides, an isoxazoline, a dichlorobenzene, a member of formamidines, an organofluorine compound and an ether.

Synthesis

The synthesis route of fluxametamide is shown in Fig. 1. As mentioned earlier, the isoxazoline 9 can be cyclized by reacting the olefin 5 and the chloroaldoxime 8 that are derived from the boronic acid 4 and the aldehyde 6, respectively. CO insertion of 9, followed by the addition of ammonia to carboxylic acid chloride, affords carbamoyl 11.

After dimethylamino methylation with N,N-dimethylformamide dimethyl acetal, the dimethylamino group can be converted into the methoxyimino group by using methox- yamine hydrochloride.
The asymmetric center of the isoxazoline ring has an insecticidal activity in its S-form, but fluxametamide was developed as a racemate.

in vitro

Fluxametamide is an antagonist of GABA- and glutamate-gated chloride channels, dose-dependently inhibits currents induced by GABA and glutamate in M. domestica GABACls and GluCls, with IC50 values of 1.95 (1.18-3.21) nM and 225 (137-372) nM, respectively, and displays potent antagonistic activity against T. urticae GABACls with an IC50 of 0.219 (0.127-0.381) nM. Fluxametamide inhibits GABA responses in the wild-type L. striatellus GABACls with IC50 values of 1.40 (0.57-3.29) nM; in the A2′N mutant GABACls, the IC50 value is 3.51 (2.17-5.69) nM. Moreover, Fluxametamide scarcely inhibits GABA (EC50)-induced currents in rat GABACls at 10 μM and with no inhibition on glycine (EC50)-induced current in human α1 GlyCls at tested concentrations.

Fluxametamide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Fluxametamide Suppliers

China 38 United States 2 Global 40

Xuzhou Hongrui Technology Co., Ltd

Tel: 18668931216
Email: 542271483@qq.com
Country: China
ProdList: 6
Advantage: 58

Madision Biomedical Co., Ltd.

Tel: 028-87439248 19150327610
Fax: 028-87439248
Email: 553691721@qq.com
Country: China
ProdList: 62
Advantage: 58

Jinan Hongkangda Chemical Co., Ltd

Tel: 0531-0531-88901705 18753193522
Email: 810353473@qq.com
Country: China
ProdList: 138
Advantage: 58

Shandong Chenxi Pharmaceutical Co., Ltd.

Tel: +86-0531-88803416 13153166250
Fax: 0531-88803416
Email: sales@chemedpharma.com
Country: China
ProdList: 249
Advantage: 58

Jinan Hongda Trading Co., Ltd.

Tel: 182-6550-6873 18265506873
Email: 439706954@qq.com
Country: China
ProdList: 128
Advantage: 58

Hangzhou J&H Chemical Co., Ltd.

Tel: +86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 10015
Advantage: 53

Nanjing XiLang Chemical Products Co., Ltd.

Tel: 025-5276156 18936048580
Email: chemxilang@163.com
Country: China
ProdList: 4008
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Zhixin Chemical Technology Co., Ltd.

Tel: 021-60441077 18701958033
Fax: 021-60441077
Email: shzxchem@163.com
Country: China
ProdList: 563
Advantage: 58

Jinan Yaoyan Pharmaceutical Co., Ltd.

Tel
Fax: -
Email: jnyaoyan@163.com
Country: China
ProdList: 3069
Advantage: 58

Shaanxi Yikunte Pharmaceutical Technology Co., Ltd.

Tel: 18049260030
Email: 380381031@qq.com
Country: China
ProdList: 509
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19105
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038; 18501792038
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9614
Advantage: 58

ChengDu SinoStandards Bio-Tech Co.,Ltd. ，

Tel: 028-83243028 19136088901
Email: sinostandards@163.com
Country: China
ProdList: 4984
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7955
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7977
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6637
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9892
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24023
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 2780
Advantage: 58

Hepharma Biology And Technology CO.,LTD.

Tel: 181-55150309 18155150309
Email: waimaobu@hepharma.cn
Country: China
ProdList: 2896
Advantage: 58

Entrenture (Lanzhou) Biomedical Technology Co., Ltd

Tel: 13919408782; 13919408782
Email: 1297709337@qq.com
Country: China
ProdList: 104
Advantage: 58

Shandong Dexin Fine Chemical Co. LTD

Tel: 13475558980 13475558980
Email: 644535754@qq.com
Country: China
ProdList: 299
Advantage: 58

Jinan zhongdaoanran chemical Co;Ltd

Tel: 18678233466 18678233466
Email: 122574856@qq.com
Country: China
ProdList: 102
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: 18143011203
Email: ET-market@chemextension.com
Country: China
ProdList: 36683
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 5347
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9180
Advantage: 58

Qingdao Dexin Chemical Co., Ltd

Tel: +8615553333686
Email: 15553333686@qq.com
Country: China
ProdList: 926
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: +undefined18143011203
Email: info@chemextension.com
Country: China
ProdList: 42057
Advantage: 58

Jinan Million Pharmaceutical Co., Ltd

Tel: +86-531-68659554 +8613031714605
Fax: Room1-2208, Gaoxin district, Jinan, Shandong
Email: info@millionpharm.com
Country: China
ProdList: 156
Advantage: 58

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8474
Advantage: 58

LEAP CHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 24738
Advantage: 58

Hainan Mike Biomedical Technology Co., Ltd

Tel: +86-15120707353 +86-18876637353
Email: tunanmedicine@hotemail.com
Country: China
ProdList: 43
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

More

Less

View Lastest Price from Fluxametamide manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: Fluxametamide 928783-29-3
Price: US $1.00-0.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2023-12-18

928783-29-3, FluxametamideRelated Search:

4-[5-(3,5-Dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[(methoxyamino)methylene]-2-methylbenzamide

FLUXAMETAMIDE

Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[(methoxyamino)methylene]-2-methyl-

Fluxametamide-002

inhibit,Inhibitor,γ-Aminobutyric acid Receptor,GABA Receptor,Fluxametamide,Gamma-aminobutyric acid Receptor

Fluxametamide(mixture of isomers)

4-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((methoxyamino)methylene)-2-methylbenzamide

928783-29-3