1303512-02-8

Product Name: 1303512-02-8
CAS No.: 1303512-02-8
Chemical Name: 1303512-02-8
Synonyms: Izilendustat;Izilendustat, 10 mM in DMSO;tert-butyl 4-((1-(4-chlorobenzyl)-3-hydroxy-2-oxo-1,2-dihydr;4-[(4-Boc-1-piperazinyl)methyl]-1-(4-chlorobenzyl)-3-hydroxypyridin-2(1H)-one;tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate;tert-butyl 4-((1-(4-chlorobenzyl)-3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)methyl)piperazine-1-carboxylate;tert-butyl 4-({1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl}methyl)piperazine-1-carboxylate;4-[1-(4-Chloro-benzyl)-3-hydroxy-2-oxo-1,2-dihydro-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-[[1-[(4-chlorophenyl)methyl]-1,2-dihydro-3-hydroxy-2-oxo-4-pyridinyl]methyl]-, 1,1-dimethylethyl ester;inmmune response,HIF-PH,colitis,prolyl hydroxylase,Inhibitor,HIF-2,HIFs,Hypoxia-inducible factors,inflammatory bowel diseases,HIF/HIF Prolyl-Hydroxylase,Izilendustat,inhibit,HIF- lα
CBNumber: CB43368615
Molecular Formula: C22H28ClN3O4
Formula Weight: 433.93
MOL File: 1303512-02-8.mol

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1303512-02-8 Property

Boiling point:: 597.8±50.0 °C(Predicted)
Density: 1.302±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (57.61 mM; ultrasonic and warming and heat to 60°C)
pka: 8.96±0.53(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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1303512-02-8 Chemical Properties,Usage,Production

Uses

Izilendustat is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2). Izilendustat has the potential for researching diseases that relate to the body’s inmmune response like colitis and other inflammatory bowel diseases (extracted from patent WO2011057115A1 and WO2011057121A1)[1][1].

References

[1] Joseph H, et al. Prolyl hydroxylase inhibitors. Patent WO2011057115A1.
[2] Joseph H, et al. Compositions and methods for treating colitis. Patent WO2011057121A1.

1303512-02-8 Preparation Products And Raw materials

Raw materials

Preparation Products

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1303512-02-8 Suppliers

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1303512-02-8, 1303512-02-8Related Search:

tert-butyl 4-((1-(4-chlorobenzyl)-3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)methyl)piperazine-1-carboxylate

1-Piperazinecarboxylic acid, 4-[[1-[(4-chlorophenyl)methyl]-1,2-dihydro-3-hydroxy-2-oxo-4-pyridinyl]methyl]-, 1,1-dimethylethyl ester

4-[1-(4-Chloro-benzyl)-3-hydroxy-2-oxo-1,2-dihydro-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester

Izilendustat

tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate

tert-butyl 4-((1-(4-chlorobenzyl)-3-hydroxy-2-oxo-1,2-dihydr

inmmune response,HIF-PH,colitis,prolyl hydroxylase,Inhibitor,HIF-2,HIFs,Hypoxia-inducible factors,inflammatory bowel diseases,HIF/HIF Prolyl-Hydroxylase,Izilendustat,inhibit,HIF- lα

4-[(4-Boc-1-piperazinyl)methyl]-1-(4-chlorobenzyl)-3-hydroxypyridin-2(1H)-one

tert-butyl 4-({1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl}methyl)piperazine-1-carboxylate

Izilendustat, 10 mM in DMSO

1303512-02-8