ChemicalBook > CAS DataBase List > (R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid

(R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid

Product Name: (R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid
CAS No.: 203640-27-1
Chemical Name: (R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid
Synonyms: S 3304, 10 mM in DMSO;R-3-(1H-Indol-3-yl)-2-(5-(p-tolyleth ynyl)thiophene-2;S 3304,Inhibitor,inhibit,S3304,MMP,S-3304,Matrix metalloproteinases;D-Tryptophan, N-[[5-[2-(4-methylphenyl)ethynyl]-2-thienyl]sulfonyl]-;(R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid;(R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid;(2R)-3-(1H-indol-3-yl)-2-{5-[2-(4-methylphenyl)ethynyl]thiophene-2-sulfonamido}propanoic acid;(2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid
CBNumber: CB43369157
Molecular Formula: C24H20N2O4S2
Formula Weight: 464.56
MOL File: 203640-27-1.mol

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(R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid Property

Boiling point:: 745.7±70.0 °C(Predicted)
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Aqueous Base (Slightly), DMSO (Slightly)
form: Solid
pka: 3.29±0.10(Predicted)
color: Pale Beige to Light Beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: S450405
Product name: S3304
Packaging: 5mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-0027075
Product name: S3304
Purity: 99.11%
Packaging: 1mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: 9655CR
Product name: D-Tryptophan,N-[[5-[2-(4-methylphenyl)ethynyl]-2-thienyl]sulfonyl]-
Packaging: 10mg
Price: $157
Updated: 2021/12/16

AK Scientific

Product number: 9655CR
Product name: D-Tryptophan,N-[[5-[2-(4-methylphenyl)ethynyl]-2-thienyl]sulfonyl]-
Packaging: 25mg
Price: $186
Updated: 2021/12/16

Activate Scientific

Product number: AS117958
Product name: S 3304
Purity: 97+%
Packaging: 1mg
Price: $196
Updated: 2021/12/16

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(R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid Chemical Properties,Usage,Production

Description

S-3304 is a sulfonamide derivative that acts as a matrix metalloproteinase inhibitor.

Uses

S 3304, is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.

in vivo

In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen^[1].

IC 50

MMP-9

(R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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203640-27-1, (R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acidRelated Search:

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(R)-3-(1H-Indol-3-yl)-2-(5-(p-tolylethynyl)thiophene-2-sulfonamido)propanoic acid

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(2R)-3-(1H-indol-3-yl)-2-{5-[2-(4-methylphenyl)ethynyl]thiophene-2-sulfonamido}propanoic acid

(2R)-3-(1H-indol-3-yl)-2-[[5-[2-(4-methylphenyl)ethynyl]thiophen-2-yl]sulfonylamino]propanoic acid

D-Tryptophan, N-[[5-[2-(4-methylphenyl)ethynyl]-2-thienyl]sulfonyl]-

(R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophene-2-sulfonylamino)-propionic acid

S 3304,Inhibitor,inhibit,S3304,MMP,S-3304,Matrix metalloproteinases

S 3304, 10 mM in DMSO

203640-27-1