ChemicalBook > CAS DataBase List > ARS-1323
ARS-1323
- Product Name
- ARS-1323
- CAS No.
- 1698024-73-5
- Chemical Name
- ARS-1323
- Synonyms
- CPD2015;ARS-1323;ARS1323;ARS 1323;ARS-1323;Inhibitor,Ras,ARS1323,ARS 1323,inhibit,ARS-1323;2-Propen-1-one, 1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-
- CBNumber
- CB43369788
- Molecular Formula
- C21H17ClF2N4O2
- Formula Weight
- 430.84
- MOL File
- 1698024-73-5.mol
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ARS-1323 Property
- Boiling point:
- 614.7±55.0 °C(Predicted)
- Density
- 1.434±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 125 mg/mL (290.13 mM)
- form
- Solid
- pka
- 6.03±0.35(Predicted)
- color
- White to off-white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- A778505
- Product name
- ARS-1620
- Packaging
- 2.5mg
- Price
- $1470
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0035015
- Product name
- ARS-1323
- Purity
- 99.14%
- Packaging
- 5mg
- Price
- $220
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC10738
- Product name
- ARS-1323
- Purity
- >98%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC10738
- Product name
- ARS-1323
- Purity
- >98%
- Packaging
- 50mg
- Price
- $800
- Updated
- 2021/12/16
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ARS-1323 Chemical Properties,Usage,Production
Uses
ARS-1620, is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
Definition
ChEBI: ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an inhibitor, an antiviral agent and an antineoplastic agent.
ARS-1323 Preparation Products And Raw materials
Raw materials
Preparation Products
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