ChemicalBook > CAS DataBase List > PTC-028

PTC-028

Product Name
PTC-028
CAS No.
1782970-28-8
Chemical Name
PTC-028
Synonyms
PTC-028;CS-1497;PTC028;PTC 028;PTC-028, 10 mM in DMSO;inhibit,Inhibitor,PTC 028,PTC-028,PTC028,Apoptosis;6-(5,6-Difluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrazinamine;2-Pyrazinamine, 6-(5,6-difluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]-;6-(5,6-Difluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N-(4-(trifluoromethyl)phenyl)pyrazin-2-amine
CBNumber
CB43370692
Molecular Formula
C19H12F5N5
Formula Weight
405.32
MOL File
1782970-28-8.mol
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PTC-028 Property

storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 1 mg/ml
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
BP168106
Product name
PTC 028
Packaging
10mg
Price
$135
Updated
2021/12/16
AK Scientific
Product number
6692DW
Product name
6-(5,6-Difluoro-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine
Packaging
10mg
Price
$232
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0009856
Product name
PTC-028
Purity
95.00%
Packaging
5MG
Price
$457.57
Updated
2021/12/16
Biosynth Carbosynth
Product number
BP168106
Product name
PTC 028
Packaging
50mg
Price
$472.5
Updated
2021/12/16
Crysdot
Product number
CD31004994
Product name
PTC-028
Purity
98%
Packaging
5mg
Price
$86
Updated
2021/12/16
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PTC-028 Chemical Properties,Usage,Production

Uses

PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis[1].

in vivo

PTC-028 (15 mg/kg; administered orally twice weekly) causes ~94% (0.169 g) reduction in tumor weight compared to the control (average tumor weight, ~3g) [1].
? No obvious toxicity is noted in the animals during therapy experiments as assessed by mean body weight[1].
? PTC-028 (10 mg/kg or 20mg/kg; single oral doses) is administrated to the CD-1 mice. The Cmax is reached at both dose levels 1h post dose after which plasma concentrations slowly reduce[1].

Animal Model:Female athymic nude mice with implanted OV90 cells[1]
Dosage:15 mg/kg
Administration:Orally administered; twice weekly
Result:Caused ~94% (0.169 g) reduction in tumor weight.
Animal Model:Female CD-1 mice[1]
Dosage:10 mg/kg or 20mg/kg
Administration:Oral administered; single dose
Result:Total plasma AUC0-24h were 10.9 and 26.1 μg?h/mL at doses of 10 and 20 mg/kg. The Cmax for PTC-028 at 10 and 20 mg/kg was 0.79 and 1.49 ug/mL, respectively.

References

[1] Dey A, et al. Evaluating the Mechanism and Therapeutic Potential of PTC-028, a Novel Inhibitor of BMI-1 Function in Ovarian Cancer. Mol Cancer Ther. 2018 Jan;17(1):39-49. DOI:10.1158/1535-7163.MCT-17-0574

PTC-028 Preparation Products And Raw materials

Raw materials

Preparation Products

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PTC-028 Suppliers

China 57 India 1 United States 5 Global 63
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
Hangzhou ChangCun Biotechnology Co., Ltd.
Tel
0571-; 13567100326
Fax
QQ158848739
Email
158848739@qq.com
Country
China
ProdList
108
Advantage
50
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58

1782970-28-8, PTC-028Related Search:


  • PTC-028
  • PTC028;PTC 028
  • CS-1497
  • 2-Pyrazinamine, 6-(5,6-difluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]-
  • 6-(5,6-Difluoro-2-methyl-1H-benzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrazinamine
  • inhibit,Inhibitor,PTC 028,PTC-028,PTC028,Apoptosis
  • 6-(5,6-Difluoro-2-methyl-1H-benzo[d]imidazol-1-yl)-N-(4-(trifluoromethyl)phenyl)pyrazin-2-amine
  • PTC-028, 10 mM in DMSO
  • 1782970-28-8
  • C19H12F5N5
  • API