ChemicalBook > CAS DataBase List > 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

Product Name
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
CAS No.
32675-71-1
Chemical Name
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
Synonyms
(Rac)-RG108;2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
CBNumber
CB43372267
Molecular Formula
C19H14N2O4
Formula Weight
334.33
MOL File
32675-71-1.mol
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2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Property

Boiling point:
606.0±50.0 °C(Predicted)
Density 
1.502±0.06 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMSO: 100mg/mL
methanol: soluble
form 
Yellow solid
pka
3.62±0.10(Predicted)
color 
yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
260920
Product name
DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem
Packaging
10mg
Price
$245
Updated
2024/03/01
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2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Chemical Properties,Usage,Production

General Description

A cell-permeable, specific DNA methyltransferases inhibitor (IC50 = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.

Biochem/physiol Actions

Cell permeable: yes

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Suppliers

China 7 Finland 1 Ukraine 1 United States 2 Global 11
Riedel-de Haen AG
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Country
United States
ProdList
6773
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Princeton BioMolecular Research, Inc.
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Email
info@princetonbio.com
Country
United States
ProdList
6934
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32675-71-1, 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acidRelated Search:


  • 2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
  • DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem
  • 1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
  • (Rac)-RG108
  • 32675-71-1