N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester
- Product Name
- N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester
- CAS No.
- 2093152-78-2
- Chemical Name
- N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester
- Synonyms
- N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester;5,8,11-Trioxa-2-azatetradecanedioic acid, 2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-, 1,14-bis(1,1-dimethylethyl) ester
- CBNumber
- CB43373714
- Molecular Formula
- C25H45NO9
- Formula Weight
- 503.63
- MOL File
- 2093152-78-2.mol
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester Property
- Boiling point:
- 546.2±50.0 °C(Predicted)
- Density
- 1.069±0.06 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DMF, DCM
- pka
- -1.61±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- BP-23468
- Product name
- N-(Propargyl-PEG2)-N-Boc-PEG3-t-butylester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- BP-23468
- Product name
- N-(Propargyl-PEG2)-N-Boc-PEG3-t-butylester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $680
- Updated
- 2021/12/16
- Product number
- BP-23468
- Product name
- N-(Propargyl-PEG2)-N-Boc-PEG3-t-butylester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $1100
- Updated
- 2021/12/16
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester Chemical Properties,Usage,Production
Description
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a click chemistry branched linker. The propargyl group can react with azide-bearing compounds through Click Chemistry, the t-butyl protected carboxyl group can also be deprotected under mild acidic conditions.
Uses
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester manufacturers
- Product
- N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester 2093152-78-2
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >95.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-28