6-(Difluoromethyl)pyridin-2-amine

Product Name: 6-(Difluoromethyl)pyridin-2-amine
CAS No.: 1315611-68-7
Chemical Name: 6-(Difluoromethyl)pyridin-2-amine
Synonyms: 6-(Difluoromethyl)pyridin-2-amine;2-Amino-6-(difluoromethyl)pyridine;2-Pyridinamine, 6-(difluoromethyl)-
CBNumber: CB43375743
Molecular Formula: C6H6F2N2
Formula Weight: 144.12
MOL File: 1315611-68-7.mol

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6-(Difluoromethyl)pyridin-2-amine Property

Boiling point:: 221.0±35.0 °C(Predicted)
Density: 1.276±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.88±0.29(Predicted)
form: liquid
color: Clear, almost colourless

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC56952
Product name: 2-Amino-6-(difluoromethyl)pyridine
Purity: 98%
Packaging: 100mg
Price: $173
Updated: 2021/12/16

Apolloscientific

Product number: PC56952
Product name: 2-Amino-6-(difluoromethyl)pyridine
Purity: 98%
Packaging: 250mg
Price: $347
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-3-7T
Product name: 2-Amino-6-(difluoromethyl)pyridine
Purity: 98%
Packaging: 250mg
Price: $383
Updated: 2021/12/16

Apolloscientific

Product number: PC56952
Product name: 2-Amino-6-(difluoromethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $688
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-3-7T
Product name: 2-Amino-6-(difluoromethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $759
Updated: 2021/12/16

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6-(Difluoromethyl)pyridin-2-amine Chemical Properties,Usage,Production

Synthesis

872365-91-8

1315611-68-7

Step 2: Synthesis of 6-(difluoromethyl)pyridin-2-amine (0398) At room temperature, 13 mL of ammonia (28 wt%) and 250 mg (1.81 mmol) of potassium carbonate were added to a solution containing 1.86 g (8.94 mmol) of 2-bromo-6-(difluoromethyl)pyridine, 64 mg (0.447 mmol) of copper (I) oxide, 80 mg (0.908 mmol) of N,N'-dimethylethylenediamine and 18 mL of ethylene glycol in a in a mixed solution. After addition, the reaction mixture was heated and stirred under reflux conditions for 22 hours. After completion of the reaction, the reaction was terminated by adding 30 mL of water and extracted with ethyl acetate (2 x 20 mL). The organic layers were combined, washed with water and then dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate = 9:1 to 6:4) to afford 770 mg of the target compound 6-(difluoromethyl)pyridin-2-amine (0398) as a colorless liquid. 1H-NMR (CDCl3, Me4Si, 300 MHz): δ 7.53 (dd, 1H, J = 7.2 Hz, 8.1 Hz), 6.94 (d, 1H, J = 7.2 Hz), 6.57 (d, 1H, J = 8.1 Hz), 6.42 (t, 1H, J = 56 Hz), 4.58 (brs, 2H).

References

[1] Patent: US2016/221998, 2016, A1. Location in patent: Paragraph 0398; 0399

6-(Difluoromethyl)pyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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1315611-68-7, 6-(Difluoromethyl)pyridin-2-amineRelated Search:

6-(Difluoromethyl)pyridin-2-amine

2-Pyridinamine, 6-(difluoromethyl)-

2-Amino-6-(difluoromethyl)pyridine

1315611-68-7