Pasireotide Acetate

Product Name: Pasireotide Acetate
CAS No.: 396091-76-2
Chemical Name: Pasireotide Acetate
Synonyms: Pasireotide Acetate;Pasireotide Acetate(acetate);Somatostatin Receptor,sst3,Inhibitor,SOM230,SOM 230,Pasireotide,proapoptotic,sst1,antiproliferative,inhibit,somatostatin,SSTRs,sst4,SOM-230,SSTR,sst5,antisecretory,Pasireotide Acetate,sst2
CBNumber: CB43379918
Molecular Formula: C60H70N10O11
Formula Weight: 1107.28
MOL File: 396091-76-2.mol

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Pasireotide Acetate Property

storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: DMSO : 100 mg/mL (90.31 mM; Need ultrasonic)
form: Solid
color: White to off-white
Sequence: Cyclo[{4-(NH2-C2H4-NH-CO-O-)Pro}-Phg-{D-Trp}-Lys-{Tyr(4-Bzl)}-Phe]

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B3596
Product name: PasireotideAcetate
Packaging: 1mg
Price: $131
Updated: 2021/12/16

ApexBio Technology

Product number: B3596
Product name: PasireotideAcetate
Packaging: 5mg
Price: $589
Updated: 2021/12/16

ApexBio Technology

Product number: B3596
Product name: PasireotideAcetate
Packaging: 10mg
Price: $1045
Updated: 2021/12/16

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Pasireotide Acetate Chemical Properties,Usage,Production

Uses

Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity[1][2][3].

in vivo

Pasireotide acetate (160 mg/kg/month; s.c. for 4 months) significantly decreases the serum insulin, increases serum glucose, reduces the tumor size and increases apoptosis in Pdx1-Cre^[2].
Pasireotide acetate (2-50 μg/kg; s.c. twice daily for 42 days) exerts the antinociceptive and antiinflammatory actions via the SSTR2 receptor in a mouse model of immune-mediated arthritis^[4].

Animal Model:	12 month-old conditional Men1 knockout mice with insulinoma^[2]
Dosage:	160 mg/kg/mouth
Administration:	S.c. every month for 4 months
Result:	Decreased the serum insulin from 1.060 μg/L to 0.3653 μg/L and increased the serum glucose from 4.246 mM to 7.122 mM. Significantly reduced the tumor size and increased apoptosis.

References

[1] Lewis I, et, al. A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential. J Med Chem. 2003 Jun 5;46(12):2334-44. DOI:10.1021/jm021093t
[2] Quinn TJ, et, al. Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model. Surgery. 2012 Dec;152(6):1068-77. DOI:10.1016/j.surg.2012.08.021
[3] Imhof AK, et, al. Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis. Arthritis Rheum. 2011 Aug;63(8):2352-62. DOI:10.1002/art.30410
[4] Schmid HA, et, al. Pasireotide (SOM230): development, mechanism of action and potential applications. Mol Cell Endocrinol. 2008 May 14;286(1-2):69-74. DOI:10.1016/j.mce.2007.09.006

Pasireotide Acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pasireotide Acetate Suppliers

China 17 United States 2 Global 19

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396091-76-2, Pasireotide AcetateRelated Search:

Pasireotide Acetate

Pasireotide Acetate(acetate)

Somatostatin Receptor,sst3,Inhibitor,SOM230,SOM 230,Pasireotide,proapoptotic,sst1,antiproliferative,inhibit,somatostatin,SSTRs,sst4,SOM-230,SSTR,sst5,antisecretory,Pasireotide Acetate,sst2

396091-76-2