CA-4948

Product Name: CA-4948
CAS No.: 1801343-74-7
Chemical Name: CA-4948
Synonyms: CA-4948;IRAK4-IN-7;IRAK4-IN-2;CA4948-Analog;CA 4948;CA4948;IRAK4-IN-7 CA-4948;CA 4948, CA-4948, CA4948;IRAK4-IN-7 (CA4948 analog);6'-Amino-N-(2-morpholinooxazolo[4,5-b]pyridin-6-yl)-[2,3'-bipyridine]-6-carboxamide;6'-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3'-bipyridine]-6-carboxamide
CBNumber: CB43379998
Molecular Formula: C21H19N7O3
Formula Weight: 417.42
MOL File: 1801343-74-7.mol

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CA-4948 Property

Melting point:: >294°C (dec.)
Density: 1.444±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 10.41±0.43(Predicted)
form: Solid
color: Pale Yellow to Brown
InChI: InChI=1S/C21H19N7O3/c22-18-5-4-13(11-23-18)15-2-1-3-16(26-15)20(29)25-14-10-17-19(24-12-14)27-21(31-17)28-6-8-30-9-7-28/h1-5,10-12H,6-9H2,(H2,22,23)(H,25,29)
InChIKey: RWIMETUXCNDSLE-UHFFFAOYSA-N
SMILES: C1(C2=CC=C(N)N=C2)=NC(C(NC2=CN=C3N=C(N4CCOCC4)OC3=C2)=O)=CC=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27598
Product name: CA-4948
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27598
Product name: CA-4948
Packaging: 25mg
Price: $571
Updated: 2024/03/01

Cayman Chemical

Product number: 27598
Product name: CA-4948
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 27598
Product name: CA-4948
Packaging: 10mg
Price: $261
Updated: 2024/03/01

TRC

Product number: A634560
Product name: 6''-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3''-bipyridine]-6-carboxamide
Packaging: 25mg
Price: $525
Updated: 2021/12/16

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CA-4948 Chemical Properties,Usage,Production

Uses

6''-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3''-bipyridine]-6-carboxamide was a useful reagent in preparation of bicyclic heterocyclyl derivatives as IRAK4 inhibitors.

General Description

CA-4948 is a novel oral small-molecule inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). IRAK4 is part of the Myddosome signaling pathway, and is essential for signaling downstream of toll-like receptors (TLR) and the interleukin-1 receptor (IL-1R) family in immune cells including B lymphocytes. . Dysregulated signaling in these pathways is frequently observed in Non-Hodgkin Lymphomas (NHL), particularly in ABC-subtype of Diffuse Large B-cell lymphoma (DLBCL) and Waldenstr?m macroglobulinemia (WM). Furthermore, IRAK4 activation has recently been identified as a driver of an adaptive resistance mechanism of malignancies. CA-4948 is the first clinical candidate targeting IRAK4 to be evaluated in cancer patients[1].

References

[1] G. Nowakowski. “Safety, Pharmacokinetics and Activity of CA-4948, an IRAK4 Inhibitor, for Treatment of Patients with Relapsed or Refractory Hematologic Malignancies: Results from the Phase 1 Study.” Blood 136 1 (2020): 44–45.

CA-4948 Preparation Products And Raw materials

Raw materials

Preparation Products

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CA-4948 Suppliers

China 74 United States 6 Global 80

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9465
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Shanghai CanSpecsci Instrument Co., Ltd.

Tel: 400-6087598 15021221957
Fax: 4006087598-8012
Email: order@canspecsci.com
Country: China
ProdList: 2051
Advantage: 56

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 4970
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8014
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9949
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29786
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131980
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

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View Lastest Price from CA-4948 manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: CA-4948 1801343-74-7
Price: US $0.00-0.00/MG
Min. Order: 1MG
Purity: 98
Supply Ability: 100G
Release date: 2024-04-17

1801343-74-7, CA-4948Related Search:

CA-4948

CA 4948, CA-4948, CA4948

IRAK4-IN-7

CA 4948;CA4948

6'-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3'-bipyridine]-6-carboxamide

[2,3'-Bipyridine]-6-carboxamide, 6'-amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl]-

CA4948-Analog

IRAK4-IN-7 (CA4948 analog)

6'-Amino-N-(2-morpholinooxazolo[4,5-b]pyridin-6-yl)-[2,3'-bipyridine]-6-carboxamide

6'-Amino-N-[2-(morpholin-4-yl)-[1,3]oxazolo[4,5-b]pyridin-6-yl]-[2,3'-bipyridine]-6-carboxamide

IRAK4-IN-7 CA-4948

ABC-type,large B cell lymphoma,IRAK4,IRAK,lymphoma,DLBCL,IRAK4 IN 7,IL-1R associated kinase,non-Hodgkin,diffuse,IRAK-4-IN-7,Interleukin-1 receptor associated kinase,Inhibitor,IRAK4IN7,inhibit

IRAK4-IN-2

6'-Amino-N-[2-(morpholin-4-yl)-[1,3]oxazolo[4,5-b]pyridin-6-yl]-[2,3'-bipyridine]-6-carboxamide

1801343-74-7