ChemicalBook > CAS DataBase List > AZD4320

AZD4320

Product Name: AZD4320
CAS No.: 1357576-48-7
Chemical Name: AZD4320
Synonyms: AZD4320;AZD4320, 10 mM in DMSO;Bcl-2 Family,Inhibitor,inhibit,AZD4320,AZD 4320,AZD-4320;4-(4-((R)-(4'-Chloro-[1,1'-biphenyl]-2-yl)(hydroxy)methyl)piperidin-1-yl)-N-((4-(((R)-4-((2-hydroxyethyl)(methyl)amino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide;Benzamide, 4-[4-[(R)-(4'-chloro[1,1'-biphenyl]-2-yl)hydroxymethyl]-1-piperidinyl]-N-[[4-[[(1R)-3-[(2-hydroxyethyl)methylamino]-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-
CBNumber: CB43380958
Molecular Formula: C45H48ClF3N4O7S3
Formula Weight: 945.53
MOL File: 1357576-48-7.mol

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AZD4320 Property

Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (132.20 mM)
form: Solid
pka: 4.70±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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AZD4320 Chemical Properties,Usage,Production

Uses

AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.

IC 50

BCL2: 17 nM (IC₅₀, KPUM-UH1 cells); BCLxL: 17 nM (IC₅₀, KPUM-UH1 cells)

References

[1] Takimoto-Shimomura T, et al. Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2. Invest New Drugs. 2018 Jun 21. DOI:10.1007/s10637-018-0623-8

AZD4320 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD4320 Suppliers

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1357576-48-7, AZD4320Related Search:

AZD 4320-d4

AZD4320

Benzamide, 4-[4-[(R)-(4'-chloro[1,1'-biphenyl]-2-yl)hydroxymethyl]-1-piperidinyl]-N-[[4-[[(1R)-3-[(2-hydroxyethyl)methylamino]-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-

Bcl-2 Family,Inhibitor,inhibit,AZD4320,AZD 4320,AZD-4320

4-(4-((R)-(4'-Chloro-[1,1'-biphenyl]-2-yl)(hydroxy)methyl)piperidin-1-yl)-N-((4-(((R)-4-((2-hydroxyethyl)(methyl)amino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide

AZD4320, 10 mM in DMSO

1357576-48-7

C45H48ClF3N4O7S3