TRIS(2-DIMETHYLAMINOETHYL)AMINE
- Product Name
- TRIS(2-DIMETHYLAMINOETHYL)AMINE
- CAS No.
- 33527-91-2
- Chemical Name
- TRIS(2-DIMETHYLAMINOETHYL)AMINE
- Synonyms
- SKL679;Me6TREN;NSC 97411;N1,N1-Bis(2-(dimethylamino);Tris(2-dimethylaminoethy)amine;Tris(2-dimethylaminoethyl)amin;TRIS(2-DIMETHYLAMINOETHYL)AMINE;Hexamethyltris(2-aminoethyl)amine;-N2,N2-dimethylethane-1,2-diamine;Tris(2-dimethylaminoethyl)amine, 99+%
- CBNumber
- CB4338176
- Molecular Formula
- C12H30N4
- Formula Weight
- 230.39
- MOL File
- 33527-91-2.mol
TRIS(2-DIMETHYLAMINOETHYL)AMINE Property
- Boiling point:
- 88℃ (1.9 Torr)
- Density
- 0.862 g/mL at 25 °C
- refractive index
- 1.4540
- Flash point:
- 104℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- clear liquid
- pka
- 8.99±0.50(Predicted)
- color
- Colorless to Light orange to Yellow
- Water Solubility
- Miscible with water.
- Sensitive
- Air Sensitive & Hygroscopic
- InChI
- InChI=1S/C12H30N4/c1-13(2)7-10-16(11-8-14(3)4)12-9-15(5)6/h7-12H2,1-6H3
- InChIKey
- VMGSQCIDWAUGLQ-UHFFFAOYSA-N
- SMILES
- C(N(CCN(C)C)CCN(C)C)CN(C)C
- EPA Substance Registry System
- 1,2-Ethanediamine, N1,N1-bis[2-(dimethylamino)ethyl]-N2,N2-dimethyl- (33527-91-2)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2735PSN1 8 / PGII
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29212900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 723142
- Product name
- Tris[2-(dimethylamino)ethyl]amine
- Purity
- 97%
- Packaging
- 1ml
- Price
- $216
- Updated
- 2025/07/31
- Product number
- T2898
- Product name
- Tris[2-(dimethylamino)ethyl]amine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $79
- Updated
- 2025/07/31
- Product number
- T2898
- Product name
- Tris[2-(dimethylamino)ethyl]amine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $269
- Updated
- 2025/07/31
- Product number
- T900623
- Product name
- Tris(2-dimethylaminoethyl)amine
- Packaging
- 2.5g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 097545
- Product name
- N1,N1-Bis(2-(dimethylamino)ethyl)-N2,N2-dimethylethane-1,2-diamine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $57
- Updated
- 2021/12/16
TRIS(2-DIMETHYLAMINOETHYL)AMINE Chemical Properties,Usage,Production
Chemical Properties
Clear colorless to yellow liquid
Uses
Tris(2-dimethylaminoethyl)amine is used as an atom transfer radical polymerization (ATRP) ligand for the creation of telechelic polymers. It is a tripodal polyamine ligand and forms complexes with group 1 metals, which is used in alkali-metal-mediated synthetic applications. Further, it is involved in the macrocyclization processes by reacting with tripodal esters in methanol to give tricyclic cryptands.
General Description
Tris[2-(dimethylamino)ethyl]amine (Me6TREN) is an aliphatic tertiary amine that forms a quadridentate ligand. It is majorly used in atom transfer radical polymerization (ATRP). It is a hexamethyl derivative of (2-aminoethyl)amine, also known as trenMe. It can be prepared by a modification of Ristempart′s synthesis.
Synthesis
50-00-0
14350-52-8
33527-91-2
Me6TREN was prepared according to the method reported in the literature [52]. The procedure was as follows: first, 30 mL of a methanol solution of 3.0 M HCl was slowly added dropwise to a 50 mL methanol solution containing 4.0 mL (0.027 mol) of tris(2-aminoethyl)amine. After the reaction mixture was stirred at room temperature for 1 hour, the precipitate was collected by filtration and washed three times with 50 mL of methanol to give 6.72 g (0.026 mol) of ClNH3CH2CH2)3NHCl in 98% yield. Subsequently, 6.72 g of ClNH3CH2CH2)3NHCl, 10 mL of distilled water, 50 mL of formic acid and 46 mL of aqueous formaldehyde were mixed. The mixture was heated in an oil bath at 120°C with stirring for 6 hours. Upon completion of the reaction, the volatile components were removed by rotary evaporation. To the solid residue was added 100 mL of a 10 wt% aqueous NaOH solution. The resulting aqueous phase was extracted four times with 100 mL of ether. The organic layers were combined, dried with anhydrous NaOH and concentrated by rotary evaporation. Finally, 6.0 g of colorless oily product was obtained in 89% yield by vacuum distillation at 62 °C. The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 2.20 (s, 18H, CH3); δ 2.3-2.37 (m, 6H, CH2); δ 2.56-2.60 (m, 6H, CH2).
References
[1] Journal of Fluorine Chemistry, 2011, vol. 132, # 9, p. 562 - 572
[2] Journal of the American Chemical Society, 1954, vol. 76, p. 2414,2417
TRIS(2-DIMETHYLAMINOETHYL)AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TRIS(2-DIMETHYLAMINOETHYL)AMINE manufacturers
- Product
- TRIS(2-DIMETHYLAMINOETHYL)AMINE 33527-91-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98
- Supply Ability
- 100kg
- Release date
- 2023-03-23
- Product
- TRIS(2-DIMETHYLAMINOETHYL)AMINE 33527-91-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-20