ChemicalBook > CAS DataBase List > 1A-116

1A-116

Product Name
1A-116
CAS No.
1430208-73-3
Chemical Name
1A-116
Synonyms
1A-116;1A-116, 10 mM in DMSO;1A-116; 1A 116; 1A116;1430208-73-3;1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine;N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine;Guanidine, N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-;1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine , 1A-116;TIAM1,inhibit,1A 116,Ras,Rho GTPases,EGF,Apoptosis,1A-116,circadian rhythms,1A116,Inhibitor
CBNumber
CB43386440
Molecular Formula
C16H16F3N3
Formula Weight
307.31
MOL File
1430208-73-3.mol
More
Less

1A-116 Property

Boiling point:
357.5±52.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 100 mg/mL (325.40 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
pka
9.78±0.10(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
A965343
Product name
1A-116
Packaging
5mg
Price
$440
Updated
2021/12/16
ChemScene
Product number
CS-8141
Product name
1A-116
Purity
99.39%
Packaging
25mg
Price
$660
Updated
2021/12/16
ChemScene
Product number
CS-8141
Product name
1A-116
Purity
99.39%
Packaging
5mg
Price
$192
Updated
2021/12/16
ChemScene
Product number
CS-8141
Product name
1A-116
Purity
99.39%
Packaging
10mg
Price
$312
Updated
2021/12/16
ChemScene
Product number
CS-8141
Product name
1A-116
Purity
99.39%
Packaging
50mg
Price
$1128
Updated
2021/12/16
More
Less

1A-116 Chemical Properties,Usage,Production

Uses

A1-116 is a novel specific Rac1 inhibitor.

in vivo

1A-116 (3 mg/kg; i.v.; once a day for 21 days) demonstrates a high antimetastatic activity with about 60% formation reduction of total metastatic lung colonies in vivo and shows no apparent toxicity[1].
? 1A-116 (20 mg/kg; i.p.; once a day, 73 days for ZT12, 68 days for ZT3) increases survival time when treated at ZT12 compare to ZT3 in tumor-bearing mice. (ZT: Zeitgeber time 12 (ZT12) defined as the time of lights off (local time 7 p.m.) and ZT0 defined as lights on (local time 7 a.m.))[2].
? 1A-116 shows good oral availability[3].

Animal Model:Female BALB/c inbred mice (8 to 10-week-old; average 20 g)[1]
Dosage:3 mg/kg
Administration:Intravenous injection; once a day for 21 days.
Result:Demonstrated a high antimetastatic activity.
Animal Model:Male NIH Swiss foxN1(?/?) nude mice (2-month-old; GBM model)[2].
Dosage:20 mg/kg
Administration:Intraperitoneal injection (at ZT3, ZT12); once a day, 73 days for ZT12, 68 days for ZT3.
Result:Increased survival time when treated at ZT12 compared to ZT3 in tumor-bearing mice.

storage

Store at -20°C

1A-116 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1A-116 Suppliers

China 41 United States 3 Global 44
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Taizhou Crene Biotechnology Co. Ltd.
Tel
+86-0576-88813233 +86-13396860566
Email
sales@pharm-intermediates.com
Country
China
ProdList
1991
Advantage
58
Shanghai Zeye Biotechnology Co., Ltd.
Tel
021-021-61998551 13122364865
Email
sale1@shzysw.net
Country
China
ProdList
9778
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Shanghai Qinli Pharmaceutical Technology Co., LTD
Tel
15921357166
Email
27960385@qq.com
Country
China
ProdList
69
Advantage
58
Zhengzhou convergence chemical co., LTD
Tel
0371-0371-55153829 18003835034
Email
2853979819@qq.com
Country
China
ProdList
9998
Advantage
58
ChemeGen
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Beijing Biocreative Technology Co., Ltd.
Tel
15522676233
Email
3007606172@qq.com
Country
China
ProdList
1248
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29995
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5002
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
Shaanxi Istare Biotechnology Co., Ltd.
Tel
18682931470; 18682931470
Email
2142355700@qq.com
Country
China
ProdList
4723
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
Tel
025-58851090 17714375163
Email
2881759498@qq.com
Country
China
ProdList
13011
Advantage
58
R&D Systems, Inc
Tel
18003437475
Fax
1-612-656-4400
Email
rdname@qq.com
Country
China
ProdList
6960
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Selleck Chemicals
Tel
400-668-6834
Email
info@selleck.cn
Country
China
ProdList
6071
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
33024
Advantage
60
Guangzhou Chuangze Biotechnology Co., Ltd.
Tel
18312220236
Country
CHINA
ProdList
178
Advantage
58
Guangzhou Suyan Biotechnology Co., Ltd
Tel
18818417021
Country
CHINA
ProdList
127
Advantage
58
Jinan Lemon Biotechnology Co., Ltd.
Tel
138000000
Email
geans@163.com
Country
China
ProdList
155
Advantage
58
Guangzhou Bingheng Biotechnology Co., Ltd.
Tel
13631342304
Country
CHINA
ProdList
188
Advantage
58
Guangzhou Yansai Biological Products Co., Ltd.
Tel
13710209565
Country
CHINA
ProdList
122
Advantage
58
Guangzhou Kangkaixin Biotechnology Co., Ltd.
Tel
13760798286
Country
CHINA
ProdList
188
Advantage
58
Biorbyt Ltd.
Tel
--
Fax
--
Email
info@biorbyt.com
Country
CHINA
ProdList
6482
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

1430208-73-3, 1A-116Related Search:


  • 1A-116
  • 1A-116; 1A 116; 1A116;1430208-73-3
  • Guanidine, N-(3,5-dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-
  • TIAM1,inhibit,1A 116,Ras,Rho GTPases,EGF,Apoptosis,1A-116,circadian rhythms,1A116,Inhibitor
  • 1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine , 1A-116
  • 1-(3,5-Dimethylphenyl)-3-(2-(trifluoromethyl)phenyl)guanidine
  • 1A-116, 10 mM in DMSO
  • N-(3,5-Dimethylphenyl)-N'-[2-(trifluoromethyl)phenyl]-guanidine
  • 1430208-73-3
  • C16H16F3N3
  • API