Gardiquimod trifluoroacetate

Product Name: Gardiquimod trifluoroacetate
CAS No.: 1159840-61-5
Chemical Name: Gardiquimod trifluoroacetate
Synonyms: Gardiquimod TFA;Gardiquimod diTFA;gardiquimod TFA salt;Gardiquimod trifluoroacetate;1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-, 2,2,2-trifluoroacetate (1:2);1-(4-Amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol bis(2,2,2-trifluoroacetate)
CBNumber: CB43386480
Molecular Formula: C19H24F3N5O3
Formula Weight: 427.43
MOL File: 1159840-61-5.mol

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Gardiquimod trifluoroacetate Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:50.0(Max Conc. mg/mL);116.98(Max Conc. mM)
Water:25.0(Max Conc. mg/mL);58.49(Max Conc. mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0032944
Product name: Gardiquimod(diTFA)
Purity: 99.77%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0032944
Product name: Gardiquimod(diTFA)
Purity: 99.77%
Packaging: 10mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0032944
Product name: Gardiquimod(diTFA)
Purity: 99.77%
Packaging: 25mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0032944
Product name: Gardiquimod(diTFA)
Purity: 99.77%
Packaging: 50mg
Price: $280
Updated: 2021/12/16

AK Scientific

Product number: 3588DF
Product name: Gardiquimodtrifluoroacetate
Packaging: 50mg
Price: $288
Updated: 2021/12/16

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Gardiquimod trifluoroacetate Chemical Properties,Usage,Production

Uses

Gardiquimod diTFA is an imidazoline TLR7/8 agonist. Gardiquimod diTFA inhibits HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically activates TLR7 at concentrations below 10 μM.

in vivo

Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) improves the anti-tumor effects of NK cells^[2].

Animal Model:	Male athymic nude mice (Balb-nu/nu, 5 weeks old) (bearing human HepG2 liver carcinoma xenografts)^[2]
Dosage:	1 mg/kg per mouse
Administration:	i.p.; daily for 7 days
Result:	Significantly suppressed the growth of human HepG2 liver carcinoma xenografts.

IC 50

TLR7; TLR8; HIV-1

References

[1] Buitendijk M, et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013 Jun;29(6):907-18. DOI:10.1089/aid.2012.0313
[2] Ma F, et al. The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice. Cell Mol Immunol. 2010 Sep;7(5):381-8. DOI:10.1038/cmi.2010.30
[3] Zhou Z, et al. TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Lett. 2015 Dec 28;369(2):298-306. DOI:10.1016/j.canlet.2015.09.017

Gardiquimod trifluoroacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Gardiquimod trifluoroacetate Suppliers

China 30 United States 3 Global 33

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1159840-61-5, Gardiquimod trifluoroacetateRelated Search:

Gardiquimod trifluoroacetate

1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-, 2,2,2-trifluoroacetate (1:2)

gardiquimod TFA salt

Gardiquimod TFA

Gardiquimod diTFA

1-(4-Amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol bis(2,2,2-trifluoroacetate)

1159840-61-5